Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2

Autor:	Ellis Owusu-Dabo, Bagrey Ngwira, Andrew P. Morris, John O. Gyapong, Andreas Ziegler, Richard A. Adegbola, Thorsten Thye, Lifted Sichali, Ivy Osei, Adrian V. S. Hill, Giorgio Sirugo, Fredrik O. Vannberg, Anthony Enimil, Margaret A. Chinbuah, Fatou Sisay-Joof, Sunny H. Wong, Simon Malema, Sian Floyd, Rolf D. Horstmann, Yik Y. Teo, Christian Lienhardt, Amelia C. Crampin, Kirk A. Rockett, Kerrin S. Small, Melanie J. Newport, Christian Meyer, Paul E. M. Fine, D. K. Warndorff, Tumani Corrah, Philip C. Hill, Dominic P. Kwiatkowski
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Genetics 0303 health sciences Linkage disequilibrium Case-control study Single-nucleotide polymorphism Genome-wide association study Odds ratio Biology Article 3. Good health 03 medical and health sciences 0302 clinical medicine Chromosome 18 030220 oncology & carcinogenesis Genetic predisposition 030304 developmental biology Genetic association
Zdroj:	Nature genetics
Popis:	We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166abd5979178690bc8288d27e166536 https://ora.ox.ac.uk/objects/uuid:16a8ea4b-aaf1-4a4f-bc28-a12a04d69109 Zobrazit plný text záznamu