Lamellar fibrosis in the fibrolamellar variant of hepatocellular carcinoma: a role for transforming growth factor beta
| Autor: | Prodromos Hytiroglou, Kamal G. Ishak, Swan N. Thung, Fiorenzo Paronetto, Giulia Orsatti |
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| Rok vydání: | 2008 |
| Předmět: |
Pathology
medicine.medical_specialty Carcinoma Hepatocellular Hepatology Growth factor medicine.medical_treatment Liver Neoplasms Transforming growth factor beta Biology HCCS medicine.disease Fibrosis Immunohistochemistry Liver Transforming Growth Factor beta Hepatocellular carcinoma Carcinoma medicine biology.protein Humans Fibrolamellar Carcinoma |
| Zdroj: | Liver. 17:152-156 |
| ISSN: | 0106-9543 |
| DOI: | 10.1111/j.1600-0676.1997.tb00798.x |
| Popis: | Transforming growth factor-beta (TGF-beta) is a pluripotent regulatory molecule, found in at least five different isoforms. It is produced in many different organs. In the liver, TGF-beta is expressed in non-parenchymal cells, but not in hepatocytes. This growth factor is known to induce fibrosis in the course of a variety of pathologic processes. Recently, TGF-beta has also been identified in hepatocellular carcinoma (HCC) cells, and the suggestion has been made that this growth factor may play a role in hepatocarcinogenesis. In this study, we report the findings of immunohistochemical stains for TGF-beta, performed on paraffin sections of 14 human HCCs of the usual type and 11 examples of the fibrolamellar variant (FLC). TGF-beta was detected in tumor cells of 3 HCCs (21%) and 9 FLCs (82%). Compared with the HCCs, the FLCs displayed a more diffuse and intense staining pattern for TGF-beta. Our findings suggest that lamellar fibrosis, which is a histologic hallmark of FLC, may be due to the action of TGF-beta produced by tumor cells. |
| Databáze: | OpenAIRE |
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