Whole Egg Consumption Decreases Cumulative Weight Gain in Diet-Induced Obese Rats
| Autor: | Kevin L. Schalinske, Amanda E Bries, Cassondra J. Saande, Matthew J. Rowling, Caitylyn A. Nass, Carter H Reed, Samantha K. Pritchard |
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| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine Calorie Sucrose Eggs Medicine (miscellaneous) 030209 endocrinology & metabolism Type 2 diabetes Biology Weight Gain Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Animal science Casein medicine Animals Insulin Obesity Triglycerides 030109 nutrition & dietetics Nutrition and Dietetics medicine.disease Diet Rats Whole egg chemistry medicine.symptom Diet-induced obese Weight gain |
| Zdroj: | The Journal of Nutrition. 150:1818-1823 |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/nxaa114 |
| Popis: | Background Whole egg (WE) consumption has been demonstrated to attenuate body weight (BW) gain and adiposity in genetic animal models of type 2 diabetes (T2D). This finding was accompanied by increased food consumption. Objectives This study aimed to examine the effects of long-term WE intake on BW gain, fat distribution, and food intake in a rat model of diet-induced obesity (DIO). Methods Male Sprague Dawley rats (n = 24) were obtained at 5 wk of age and were randomly weight-matched across 1 of 4 dietary intervention groups (6 rats per group): a casein-based diet (CAS), a high-fat high-sucrose CAS diet (HFHS CAS), a whole egg–based diet (EGG), or a high-fat high-sucrose EGG diet (HFHS EGG). All diets provided 20% (w/w) protein and were provided for 33 wk. HFHS diets provided ∼61% of kilocalories from fat and 10% from sucrose. Daily weight gain and food intake were recorded, biochemical parameters were measured via ELISA, and epididymal fat pad weights were recorded at the end of the study. Results At 33 wk, cumulative BW gain in DIO rats fed HFHS EGG resulted in 23% lower weight gain compared with DIO rats fed HFHS CAS (P < 0.0001), but no significant differences in BW gain were observed between the HFHS EGG group and the control EGG and CAS groups (P = 0.71 and P = 0.61, respectively). Relative food intake (grams per kilogram BW) was 23% lower (P < 0.0001) in rats fed HFHS CAS compared with CAS, whereas there was no difference in food intake within the EGG dietary groups. DIO rats fed HFHS EGG exhibited a 22% decrease in epididymal fat weight compared with their counterparts fed the HFHS CAS. Conclusions Our data demonstrate that consumption of a WE-based diet reduced BW gain and visceral fat in the DIO rat, similar to our previous findings in a genetic rat model with T2D. |
| Databáze: | OpenAIRE |
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