Flattening of Diluted Species Profile via Passive Geometry in a Microfluidic Device
| Autor: | Apresio K. Fajrial, Michael H. B. Stowell, William M. Old, Yung-Cheng Lee, Xiaoyun Ding, Nakul Sridhar, Kerri A. Ball, Biddut Bhattacharjee, Michael J. Miles |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
Microfluidics microfluidics 02 engineering and technology 01 natural sciences Article Flattening law.invention law Microfluidic channel Fluid dynamics Electrical and Electronic Engineering Mechanical Engineering 010401 analytical chemistry Mechanics lab on a chip Lab-on-a-chip 021001 nanoscience & nanotechnology flow control Finite element method 0104 chemical sciences flow profile Flow control (fluid) Control and Systems Engineering Potential flow 0210 nano-technology |
| Zdroj: | Micromachines Volume 10 Issue 12 |
| ISSN: | 2072-666X |
| DOI: | 10.3390/mi10120839 |
| Popis: | In recent years, microfluidic devices have become an important tool for use in lab-on-a-chip processes, including drug screening and delivery, bio-chemical reactions, sample preparation and analysis, chemotaxis, and separations. In many such processes, a flat cross-sectional concentration profile with uniform flow velocity across the channel is desired to achieve controlled and precise solute transport. This is often accommodated by the use of electroosmotic flow, however, it is not an ideal for many applications, particularly biomicrofluidics. Meanwhile, pressure-driven systems generally exhibit a parabolic cross-sectional concentration profile through a channel. We draw inspiration from finite element fluid dynamics simulations to design and fabricate a practical solution to achieving a flat solute concentration profile in a two-dimensional (2D) microfluidic channel. The channel possesses geometric features to passively flatten the solute profile before entering the defined region of interest in the microfluidic channel. An obviously flat solute profile across the channel is demonstrated in both simulation and experiment. This technology readily lends itself to many microfluidic applications which require controlled solute transport in pressure driven systems. |
| Databáze: | OpenAIRE |
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