The impact of age on long-term behavioral and neurochemical parameters in an animal model of severe sepsis
| Autor: | Amanda Indalécio, Monique Michels, Pricila Ávila, Cristiane Ritter, Mariane Abatti, Henrique Burger, Maria Vitoria Meller Milioli, Rodrigo Olivieri, Felipe Dal-Pizzol |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Time Factors medicine.medical_treatment Interleukin-1beta Perforation (oil well) Prefrontal Cortex Hippocampus Inflammation Sepsis 03 medical and health sciences Cognition 0302 clinical medicine Neurochemical Internal medicine Animals Medicine Prefrontal cortex Amyloid beta-Peptides Behavior Animal Depression Interleukin-6 business.industry General Neuroscience Age Factors medicine.disease Rats Oxidative Stress 030104 developmental biology Endocrinology Cytokine medicine.symptom business 030217 neurology & neurosurgery Behavioural despair test |
| Zdroj: | Neuroscience Letters. 708:134339 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2019.134339 |
| Popis: | This study aimed to evaluate behavioral and neurochemical parameters in adult (180-day-old) and young (60-day-old) rats subjected to sepsis. Sepsis was induced by cecal ligation and perforation (CLP). Thirty days after surgery, behavioral tests were performed, and the β-amyloid content, oxidative damage, and cytokine levels were measured in the hippocampus and prefrontal cortex. In both adult and young rats, sepsis impaired the inhibitory avoidance task performance and increased immobility time in the forced swimming test. However, the adult septic rats had a higher immobility time compared to the young rats. Both sepsis and aging induced brain inflammation and oxidative damage and increased Aβ content. Sepsis along with aging had additive effects on hippocampal interleukin-1 levels and prefrontal carbonyl levels. Taken together, our results suggest that age has a minor influence on brain inflammation and behavioral alterations observed in septic rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect