Site-Selective Intermolecular Oxidative C-3 Alkenylation of 7-Azaindoles at Room Temperature

Autor:	K. Anil Kumar, Parthasarathi Das, Prakash Kannaboina
Rok vydání:	2016
Předmět:	010405 organic chemistry Ligand Chemistry Organic Chemistry Intermolecular force Oxidative phosphorylation 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis Site selective Molecular oxygen Physical and Theoretical Chemistry
Zdroj:	Organic Letters. 18:900-903
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.5b03429
Popis:	A previously unexplored palladium-catalyzed C-3 selective alkenylation of 7-azaindoles, performed in the presence of Pd(OAc)2 as the catalyst, PPh3 as the ligand, Cu(OTf)2 as an oxidative cocatalyst, and molecular oxygen (O2) as the terminal oxidant at room temperature, has been reported. This direct alkenylation strategy offers a new approach in functionalizing pharmaceutically important 7-azaindoles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161496bc5ac742b85e32da3fad2ffd16 https://doi.org/10.1021/acs.orglett.5b03429 Zobrazit plný text záznamu