Dietary and metabolic factors in the pathogenesis of hidradenitis suppurativa: a systematic review
| Autor: | Franchesca Choi, Larisa M. Lehmer, Natasha Atanaskova Mesinkovska, Chloe Ekelem |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Diet Reducing Population Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Weight loss Internal medicine Weight Loss Vitamin D and neurology medicine Humans Hidradenitis suppurativa Micronutrients Obesity Vitamin D education education.field_of_study business.industry Odds ratio Micronutrient medicine.disease Diet Hidradenitis Suppurativa Vitamin B 12 Zinc 030220 oncology & carcinogenesis Meta-analysis medicine.symptom business |
| Zdroj: | International journal of dermatologyReferences. 59(2) |
| ISSN: | 1365-4632 |
| Popis: | Hidradenitis suppurativa (HS) is a systemic recalcitrant inflammatory condition characterized by debilitating lesions with high morbidity. Its known association with obesity and smoking indicate correlation with other environmental factors, such as diet, suggesting a larger role for lifestyle modifications in disease treatment. This study seeks to assess the contribution of weight loss and dietary intake in HS management. A primary literature search was conducted using PubMed, Web of Science, and CINAHL in November 2018 to include association and intervention studies on the influence of diet and weight on HS. Twenty-five articles were included. Meta-analysis of nine case-control studies across Asia, Europe, and the United States showed that HS patients are four times more likely to be obese compared to the general population; random effects pooled odds ratio 4.022 (2.667-6.065), P < 0.001. Five articles assessed weight-loss interventions and revealed mixed findings. The remaining articles included three association studies on micronutrient levels, eight dietary intervention studies, and one article analyzing both micronutrient association and dietary intervention. Included articles in this systematic review reveal that low serum zinc and vitamin D levels are associated with increased lesion count in HS. Supplementation of zinc, vitamin D, vitamin B12, or exclusion of dairy or brewer's yeast can be effective in partial or complete lesion resolution. Reviewed data show that weight loss from bariatric surgery may lead to HS improvement but often results in more severe malnutrition that worsens or even leads to new onset HS post bariatric surgery. Future reporting is needed to conclusively determine the role of diet in HS. |
| Databáze: | OpenAIRE |
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