β-cell function in black South African women: exploratory associations with insulin clearance, visceral and ectopic fat
| Autor: | Louise M Goff, Julia H. Goedecke, Amy E. Mendham, Jeroen Swart, Steven E Kahn, Ali Alhamud, Melony C Fortuin-de Smidt, Jon Hauksson, Olah Hakim, Darko Stefanovski, Tommy Olsson |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
β cell function medicine.medical_specialty insulin secretion β-cell function Endocrinology Diabetes and Metabolism medicine.medical_treatment ectopic fat Adipose tissue 030209 endocrinology & metabolism Type 2 diabetes Endocrinology and Diabetes Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine hepatic insulin extraction Internal Medicine medicine Hyperinsulinemia Insulin secretion business.industry Insulin Research medicine.disease RC648-665 Obesity peripheral insulin clearance 030104 developmental biology Endokrinologi och diabetes Beta cell business |
| Zdroj: | Endocrine Connections, Vol 10, Iss 5, Pp 550-560 (2021) Endocrine Connections |
| ISSN: | 2049-3614 |
| Popis: | The role of ectopic fat, insulin secretion and clearance in the preservation ofβ-cell function in black African women with obesity who typically present with hyperinsulinaemia is not clear. We aim to examine the associations between disposition index (DI, an estimate of β-cell function), insulin secretion and clearance and ectopic fat deposition. This is a cross-sectional study of 43 black South African women (age 20–35 years) with obesity (BMI 30–40 kg/m2) and without type 2 diabetes that measured the following: DI, insulin sensitivity (SI), acute insulin response (AIRg), insulin secretion rate (ISR), hepatic insulin extraction and peripheral insulin clearance (frequently sampled i.v. glucose tolerance test); pancreatic and hepatic fat, visceral adipose tissue (VAT) and abdominal s.c. adipose tissue (aSAT) volume (MRI), intra-myocellular (IMCL) and extra-myocellular fat content (EMCL) (magnetic resonance spectroscopy). DI correlated positively with peripheral insulin clearance (β 55.80, P = 0.002). Higher DI was associated with lower VAT, pancreatic fat and soleus fat, but VAT explained most of the variance in DI (32%). Additionally, higher first phase ISR (P = 0.033) and lower hepatic insulin extraction (P = 0.022) were associated with lower VAT, independent from SI, rather than with ectopic fat. In conclusion, peripheral insulin clearance emerged as an important correlate of DI. However, VAT was the main determinant of a lower DI above ectopic fat depots. Importantly, VAT, but not ectopic fat, is associated with both lower insulin secretion and higher hepatic insulin extraction. Prevention of VAT accumulation in young black African women should, therefore, be an important target for beta cell preservation. |
| Databáze: | OpenAIRE |
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