Comparison of Clinical Outcomes in Patients With Localized or Locally Advanced Urothelial Carcinoma Treated With Neoadjuvant Chemotherapy Involving Gemcitabine-Cisplatin and High Dose-Intensity MVAC

Autor:	Yongjune Lee, Young Seok Kim, Jae-Lyun Lee, Bumsik Hong, Yong Mee Cho
Rok vydání:	2021
Předmět:	0301 basic medicine Adult Male Cancer Research medicine.medical_specialty Urologic Neoplasms medicine.medical_treatment Urology Vinblastine Deoxycytidine 03 medical and health sciences 0302 clinical medicine Clinical Trials Phase II as Topic Antineoplastic Combined Chemotherapy Protocols medicine Humans Neoplasm Invasiveness Aged Randomized Controlled Trials as Topic Retrospective Studies Cisplatin Aged 80 and over Chemotherapy Bladder cancer business.industry General Medicine Middle Aged medicine.disease Gemcitabine Survival Rate Regimen 030104 developmental biology Methotrexate Oncology Clinical Trials Phase III as Topic Urinary Bladder Neoplasms Doxorubicin 030220 oncology & carcinogenesis Female business Febrile neutropenia medicine.drug
DOI:	10.21203/rs.3.rs-164451/v1
Popis:	PurposeTo compare the efficacy and safety of high dose-intensity combination of methotrexate, vinblastine, adriamycin and cisplatin (HD MVAC) with gemcitabine plus cisplatin (GC) as a neoadjuvant chemotherapy (NAC) in muscle-invasive bladder cancer (MIBC) or locally advanced upper tract urothelial cancer (UTUC). Patients and MethodsA retrospective analysis was conducted for patients with UC (cT2-4aN0-1M0) who received NAC from January 2011 and December 2017 at Asan Medical Center. Pathologic complete response (pCR), down-staging (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ffa5d355202f84c72c9feaafa202b8 https://doi.org/10.21203/rs.3.rs-164451/v1 Zobrazit plný text záznamu