Prognostic immunohistochemical markers of primary human melanomas
| Autor: | A. Lippold, B. Fuchs, F. Otto, R. Mawick, Ludwig Suter, V. Krieg, Ostmeier H |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male HLA-DP Antigens Pathology medicine.medical_specialty Skin Neoplasms Multivariate analysis Mitotic index Adolescent Transferrin receptor CD146 Antigen Dermatology Disease-Free Survival Sex Factors Antigens CD HLA-DQ Antigens Receptors Transferrin Biomarkers Tumor Mitotic Index Frozen Sections Humans Medicine Child Melanoma Neural Cell Adhesion Molecules Aged Frozen section procedure Membrane Glycoproteins biology Proportional hazards model business.industry Age Factors Infant Newborn Univariate Infant Middle Aged Prognosis Ki-67 Antigen Child Preschool Ki-67 biology.protein Regression Analysis Immunohistochemistry Female business |
| Zdroj: | British Journal of Dermatology. 145:203-209 |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1046/j.1365-2133.2001.04335.x |
| Popis: | Background Several clinical and histological factors of primary melanomas comprise a relatively large quantity of prognostic information. Objective To find immunohistochemical markers that can improve the prognostic accuracy achieved by factors that are available without extra laboratory work, i.e. mitotic rate, tumour thickness, ulceration, localization, gender and age. Methods Immunohistochemical markers were determined on frozen sections. Univariate and multivariate Cox regression analyses were performed after 5–10 years follow-up. Results Seven immunohistochemical markers were related to disease-free and overall survival in univariate Cox regression analysis: Ki-67, human leucocyte antigen (HLA) -DQ, HLA-DP, Muc 18, A-10-33, transferrin receptor, and H-2-8-10. Only Ki-67 (n = 399) and HLA-DQ (n = 452) retained prognostic significance when evaluated in multivariate analyses in several models together with tumour thickness alone and with tumour thickness, gender, mitotic rate, age, localization and ulceration. Conclusions Ki-67 and HLA-DQ may be useful for risk assessments in primary melanomas. |
| Databáze: | OpenAIRE |
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