Search for Epstein-Barr and type C oncornaviruses in systemic lupus erythematosus
| Autor: | Aulakh Gs, McGrath Pp, Kim E, Washington Gc, Alepa Fp, Hicks Jt |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Herpesvirus 4
Human viruses Immunology Endogeny Biology Lymphocyte Activation Virus Cell Line Rheumatology Immunology and Allergy Humans Lupus Erythematosus Systemic Pharmacology (medical) Lymphocytes B-Lymphocytes Lymphoblast Nucleic Acid Hybridization RNA-Directed DNA Polymerase Virology Reverse transcriptase Oncornavirus Transformation (genetics) Retroviridae Lymphoblastoid cell Bromodeoxyuridine Epstein barr |
| Zdroj: | Arthritis and rheumatism. 22(8) |
| ISSN: | 0004-3591 |
| Popis: | Lymphoblastoid cell lines were derived from patients with active systemic lupus erythematosus by allowing spontaneous transformation of peripheral B lymphocytes (B cells) harboring endogenous Epstein-Barr virus or by superinfecting peripheral lymphocytes with exogeneous Epstein-Barr virus. Results of extensive studies aimed at identifying type C oncornaviruses in these lymphoblastoid cells were entirely negative by electron microscopy, DNA-DNA hybridization, reverse transcriptase assays, and cocultivation experiments. These results do not support the postulated association of oncornavirus infection in human systemic erythematosus. |
| Databáze: | OpenAIRE |
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