Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities
| Autor: | Ana M.M. Oliveira, Thekla J. Hemstedt, Hilmar Bading |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
0303 health sciences
General Neuroscience Hippocampus Cognition Normal aging Hippocampal formation DNA methyltransferase 03 medical and health sciences 0302 clinical medicine Expression (architecture) Young adult Psychology Immediate early gene Neuroscience 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Nature Neuroscience. |
| Popis: | Cognitive abilities decline in normal aging, yet the underlying molecular mechanisms are poorly understood. We found that aging was associated with a decrease in the expression of the DNA methyltransferase Dnmt3a2 in the hippocampus and that rescuing Dnmt3a2 levels restored cognitive functions. Moreover, we found that Dnmt3a2 is an activity-regulated immediate early gene that is partly dependent on nuclear calcium signaling and that hippocampal Dnmt3a2 levels determine cognitive abilities in both young adult and aged mice. |
| Databáze: | OpenAIRE |
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