Donor and Recipient BKV-Specific IgG Antibody and Posttransplantation BKV Infection
| Autor: | Scott K. Van-Why, Sundaram Hariharan, Shamila Senanayake, Christopher P. Johnson, Radhika Medipalli, Kumar Sujeet, Puneet Sood, David Cronin |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Graft Rejection Male Adolescent viruses Enzyme-Linked Immunosorbent Assay Viremia Single Center medicine.disease_cause Antibodies Postoperative Complications medicine Humans Prospective Studies Child Prospective cohort study Aged Polyomavirus Infections Transplantation Graft rejection biology business.industry virus diseases Specific igg Middle Aged medicine.disease Virology BK virus Tumor Virus Infections Treatment Outcome BK Virus Immunoglobulin G biology.protein Female Antibody Serostatus business |
| Zdroj: | Transplantation. 95:896-902 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/tp.0b013e318282ba83 |
| Popis: | BACKGROUND: The study evaluated the relationship of pretransplantation BK virus (BKV)-specific donor and recipient serostatus to posttransplantation BKV infection. METHODS: Two hundred forty adult de novo kidney-only recipients and 15 pediatric recipients were prospectively enrolled and followed for a minimum of 18 months. Pretransplantation BKV serostatus was available for 192 adult and 11 pediatric donor-recipient pairs. Based on BKV-specific IgG enzyme immunoassay ≥8 units, subjects were divided into four groups: D+R+, D+R-, D-R+, and D-R-. BKV DNA surveillance was performed at 1, 3, 6, 12, and 24 months. The outcomes studied were development of any BKV infection, viremia, and significant viremia (≥10,000 copies/mL plasma). RESULTS: Of the 192 adult subjects (D+R- [n=41], D+R+ [n=42], D-R+ [n=41], and D-R- [n=68]), 89 of 192 developed any BKV infection and 62 of 89 developed BK insignificant viremia (n=33) and significant viremia (n=29). Any BKV infection developed in 25 of 41, 22 of 42, 17 of 41, and 25 of 68 in the D+R-, D+R+, D-R+, and D-R- groups, respectively. Any viremia (20 of 41) and significant viremia (10 of 41) seen in the D+R- group was significantly higher than other groups (P=0.014). In 11 pediatric recipients, infection was seen only in the D+R- group. Overall, infection was highest in the D+R- group and lowest in the D-R- group. CONCLUSIONS: BKV serostatus can be used to risk stratify patients for posttransplantation infection. |
| Databáze: | OpenAIRE |
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