Acute Dietary Nitrate Supplementation Improves Flow Mediated Dilatation of the Superficial Femoral Artery in Healthy Older Males
| Autor: | Jason D. Allen, Tom G. Bailey, Christopher D. Askew, Daniel J. Green, Luke C. McIlvenna, Meegan Walker |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
inorganic chemicals 0301 basic medicine cardiovascular risk medicine.medical_specialty beetroot juice Blood Pressure lcsh:TX341-641 Femoral artery 030204 cardiovascular system & hematology Beetroot Juice Placebo Article 03 medical and health sciences Hyperaemia 0302 clinical medicine endothelial function nitric oxide medicine.artery Internal medicine Blood plasma medicine Humans blood flow Pulse wave velocity Aged Nitrates Nutrition and Dietetics business.industry food and beverages Middle Aged medicine.disease body regions Femoral Artery Vasodilation 030104 developmental biology Blood pressure arterial stiffness Dietary Supplements cardiovascular system Cardiology Arterial stiffness medicine.symptom business lcsh:Nutrition. Foods and food supply Food Science inorganic nitrate |
| Zdroj: | Nutrients, Vol 11, Iss 5, p 954 (2019) Nutrients Volume 11 Issue 5 |
| ISSN: | 2072-6643 |
| Popis: | Aging is often associated with reduced leg blood flow, increased arterial stiffness, and endothelial dysfunction, all of which are related to declining nitric oxide (NO) bioavailability. Flow mediated dilatation (FMD) and passive leg movement (PLM) hyperaemia are two techniques used to measure NO-dependent vascular function. We hypothesised that acute dietary nitrate (NO3&minus ) supplementation would improve NO bioavailability, leg FMD, and PLM hyperaemia. Fifteen healthy older men (69 ± 4 years) attended two experiment sessions and consumed either 140 mL of concentrated beetroot juice (800 mg NO3&minus ) or placebo (NO3&minus depleted beetroot juice) in a randomised, double blind, cross-over design study. Plasma nitrite (NO2&minus ) and NO3&minus blood pressure (BP), augmentation index (AIx75), pulse wave velocity (PWV), FMD of the superficial femoral artery, and PLM hyperaemia were measured immediately before and 2.5 h after consuming NO3&minus and placebo. Placebo had no effect but NO3&minus led to an 8.6-fold increase in plasma NO2&minus which was accompanied by an increase in FMD (NO3&minus +1.18 ± 0.94% vs. placebo: 0.23 ± 1.13%, p = 0.002), and a reduction in AIx75 (NO3&minus &minus 8.7 ± 11.6% vs. placebo: &minus 4.6 ± 5.5%, p = 0.027). PLM hyperaemia, BP, and PWV were unchanged during both trials. This study showed that a dose of dietary NO3&minus improved NO bioavailability and enhanced endothelial function as measured by femoral artery FMD. These findings provide insight into the specific central and peripheral vascular responses to dietary NO3&minus supplementation in older adults. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|