| Autor: |
J.-P. Pelletier, Alain Bosseloir, Michelle Deberg, Christelle Boileau, B Guillou, J. Caron, Philippe Msika, Johanne Martel-Pelletier, Yves Henrotin |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
Osteoarthritis and Cartilage. 16 |
| ISSN: |
1063-4584 |
| DOI: |
10.1016/s1063-4584(08)60132-6 |
| Popis: |
After six months: VAS, uCTX-I and uCTX-II. After one year: VAS, uCTX-I, uCTX-II and radiographs. Results: After 6 months and 1 year of treatment VAS, uCTX-I and uCTXII mean values were significantly lower than the baseline. 57 were treated with GCC and 47 with GC. The group that received GCC showed a similar VAS mean value after 6 months and 1 year when compared with the group treated with GC. uCTX-I and uCTX-II mean level was lower in the group treated with GCC (p< 0.05). Radiological score (Kellgren and Lawrence summarized score for hands) after 1 year showed a reduced progression compared to the baseline in the hand osteoarthritis group, especially after GCC treatment (p< 0.05). Finally, uCTX-I has better correlation with radiological score and with GC in the EOA subgroup (Pearson index: R=0.44). Conclusions: (a) uCTX-I and uCTX-II proved to be useful biomarkers in OAmonitoring; (b) uCTX-I is better correlated with hand EOA and could represent a potential further marker to asses the evolution of EOA bone damage; (c) glucosamine and chondroitinsulphate slow down OA progression; (d) finally COLLII could represent a further protective factor in OA cartilage. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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