Hepatocyte and Sertoli Cell Aquaporins, Recent Advances and Research Trends

Autor: Raquel L. Bernardino, Maria Svelto, Raúl A. Marinelli, Patrizia Gena, Giuseppe Calamita, Ilaria Cataldo, Marco G. Alves, Anna Maggio, Pedro Oliveira
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Review
Mitochondrion
Energy homeostasis
male fertility
lcsh:Chemistry
Non-alcoholic Fatty Liver Disease
lcsh:QH301-705.5
Spectroscopy
Bile Formation
Fatty liver
General Medicine
Sertoli cell
3. Good health
Computer Science Applications
Mitochondria
medicine.anatomical_structure
Biochemistry
Hepatocyte
Male Fertility
Aquaporin
Biology
testis
Aquaporins
reactive oxygen species (ROS)
liver
Catalysis
Inorganic Chemistry
03 medical and health sciences
bile formation
Cholestasis
medicine
Humans
Physical and Theoretical Chemistry
Spermatogenesis
Molecular Biology
Infertility
Male
Sertoli Cells
Organic Chemistry
Metabolic Homeostasis
Non-Alcoholic Fatty Liver Disease (NAFLD)
Lipid metabolism
medicine.disease
spermatogenesis
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Hepatocytes
Energy Metabolism
Reactive Oxygen Species
metabolic homeostasis
Zdroj: International Journal of Molecular Sciences
RepHipUNR (UNR)
Universidad Nacional de Rosario
instacron:UNR
International Journal of Molecular Sciences, Vol 17, Iss 7, p 1096 (2016)
ISSN: 1422-0067
Popis: Aquaporins (AQPs) are proteinaceous channels widespread in nature where they allow facilitated permeation of water and uncharged through cellular membranes. AQPs play a number of important roles in both health and disease. This review focuses on the most recent advances and research trends regarding the expression and modulation, as well as physiological and pathophysiological functions of AQPs in hepatocytes and Sertoli cells (SCs). Besides their involvement in bile formation, hepatocyte AQPs are involved in maintaining energy balance acting in hepatic gluconeogenesis and lipid metabolism, and in critical processes such as ammonia detoxification and mitochondrial output of hydrogen peroxide. Roles are played in clinical disorders including fatty liver disease, diabetes, obesity, cholestasis, hepatic cirrhosis and hepatocarcinoma. In the seminiferous tubules, particularly in SCs, AQPs are also widely expressed and seem to be implicated in the various stages of spermatogenesis. Like in hepatocytes, AQPs may be involved in maintaining energy homeostasis in these cells and have a major role in the metabolic cooperation established in the testicular tissue. Altogether, this information represents the mainstay of current and future investigation in an expanding field. Para citar este articulo: Bernardino, R.L.; Marinelli, R.A.; Maggio, A.; Gena, P.; Cataldo, I.; Alves, M.G.; Svelto, M.; Oliveira, P.F.; Calamita, G. Hepatocyte and Sertoli Cell Aquaporins, Recent Advances and Research Trends. Int. J. Mol. Sci. 2016, 17, 1096. https://doi.org/10.3390/ijms17071096 Fil: Bernardino, Raquel L. University of Porto. Institute of Biomedical Sciences Abel Salazar (ICBAS). Unit for Multidisciplinary Research in Biomedicine (UMIB); Portugal. Fil: Bernardino, Raquel L. University of Porto. Institute of Biomedical Sciences Abel Salazar (ICBAS). Department of Microscopy, Laboratory of Cell Biology; Portugal. Fil: Marinelli, Raúl A. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE -CONICET); Argentina. Fil: Maggio, Anna. University of Bari “Aldo Moro”. Department of Biosciences, Biotechnologies and Biopharnaceutics; Italy. Fil: Gena, Patrizia. University of Bari “Aldo Moro”. Department of Biosciences, Biotechnologies and Biopharnaceutics; Italy. Fil: Cataldo, Ilaria. University of Bari “Aldo Moro”. Department of Biosciences, Biotechnologies and Biopharnaceutics; Italy. Fil: Alves, Marco G. University of Beira Interior. CICS-UBI, Health Sciences Research Centre; Portugal. Fil: Svelto, María. University of Bari “Aldo Moro”. Department of Biosciences, Biotechnologies and Biopharnaceutics; Italy. Fil: Oliveira, Pedro F. University of Porto. Institute of Biomedical Sciences Abel Salazar (ICBAS). Unit for Multidisciplinary Research in Biomedicine (UMIB); Portugal. Fil: Oliveira, Pedro F. University of Porto. Institute of Biomedical Sciences Abel Salazar (ICBAS). Department of Microscopy, Laboratory of Cell Biology; Portugal. Fil: Oliveira, Pedro F. Universidade do Porto. Instituto de Investigação e Inovação em Saúde; Portugal. Fil: Calamita, Giuseppe. University of Bari “Aldo Moro”. Department of Biosciences, Biotechnologies and Biopharmaceutics; Italy.
Databáze: OpenAIRE
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