Resistance to oxidative damage but not immunosuppression by organic tin compounds in natural populations of Daubenton's bats (Myotis daubentonii)
| Autor: | Mirella Kanerva, Esa-Matti Lilius, Janne Atosuo, Axel Meierjohann, Mikko Nikinmaa, Lasse Ruokolainen, Janina Stauffer, Veronika N. Laine, Thomas M. Lilley |
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| Rok vydání: | 2013 |
| Předmět: |
Geologic Sediments
Food Chain Physiology Health Toxicology and Mutagenesis Metabolite media_common.quotation_subject Zoology 010501 environmental sciences Biology Toxicology 01 natural sciences Biochemistry Redox Mass Spectrometry 03 medical and health sciences chemistry.chemical_compound Chiroptera Immune Tolerance Organotin Compounds Animals Finland 030304 developmental biology 0105 earth and related environmental sciences Apex predator media_common chemistry.chemical_classification 0303 health sciences Reactive oxygen species Dose-Response Relationship Drug Ecology ta1184 Longevity Sediment Cell Biology General Medicine Acute toxicity Oxidative Stress chemistry 13. Climate action Tributyltin ta1181 Trialkyltin Compounds Water Pollutants Chemical |
| Zdroj: | Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 157:298-305 |
| ISSN: | 1532-0456 |
| DOI: | 10.1016/j.cbpc.2013.01.003 |
| Popis: | The acute toxicity of organic tin compounds (OTCs) has been studied in detail. However, due to their complex nature, very little is known about species-specific methods of accumulation and consequences for food-webs. Chironomids, on which e.g. Daubenton's bats feed, may act as vectors for the transport of organic tin compounds from aquatic to terrestrial ecosystems. Bats are prone to environmental toxins because of their longevity and their ecological role as top predators. Organic tin compounds are associated with increased formation of reactive oxygen species and associated oxidative damage as well as suppression of immune function. The present paper investigates whether the OTC, tributyltin (TBT) and its metabolite, dibutyltin (DBT), accumulate in natural populations of Daubenton's bats and whether TBT-associated effects are seen in general body condition, redox balance, redox enzyme activities, associated oxidative damage of red blood cells and complement function. We discovered the concentration of bat fur DBT correlated with local marine sediment TBT concentrations. However, we did not find a correlation between the explanatory factors, bat fur DBT and marine sediment TBT concentrations, and several physiological and physical response variables apart from complement activity. Higher DBT concentrations resulted in weaker complement activity and thus a weaker immune response. Although the observed physiological effects in the present study were not strongly correlated to butyltin concentrations in fur or sediment, the result is unique for natural populations so far and raises interesting questions for future ecotoxicological studies. |
| Databáze: | OpenAIRE |
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