Delayed effects of hypotensive drugs on structural characteristics of the renal glomerular system in hypertensive NISAG rats
| Autor: | I. I. Buzuyeva, Arcady L. Markel, M. D. Shmerling, E. E. Filyushina, V. A. Lazarev, G. S. Yakobson |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Nifedipine Kidney Glomerulus Pharmacology Hypotensive Drugs Losartan General Biochemistry Genetics and Molecular Biology Terazosin Enalapril Internal medicine medicine Animals Channel blocker Antihypertensive Agents Kidney business.industry Prazosin General Medicine Rats Blockade medicine.anatomical_structure Endocrinology Hypertension business medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 143:749-752 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-007-0232-6 |
| Popis: | Comparative morphometrical study of the renal glomerular system was carried out in hypertensive NISAG rats treated with hypotensive drugs during the prepubertal period. Blockade of the renin-angiotensin system with enalapril or losartan during the critical period of ontogeny (the 2nd month of life) produced a long-term hypotensive and renoprotective effect. Treatment with alpha-adrenoblocker terazosin during this period of ontogeny produced a less pronounced hypotensive effect, though with renoprotection. Corinfar (Ca2+ channel blocker) was least effective. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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