Chemo-Mechanical Modulation of Cell Motions Using DNA Nanosprings
| Autor: | Sagun Jonchhe, Deepak Karna, Kazuya Ankai, Yao-Rong Zheng, Yuki Suzuki, Morgan Stilgenbauer, Hanbin Mao, Yunxi Cui, Ibuki Kawamata |
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| Rok vydání: | 2021 |
| Předmět: |
Cell
Integrin Biomedical Engineering Pharmaceutical Science Bioengineering 02 engineering and technology 01 natural sciences Article Cell membrane chemistry.chemical_compound Cell Movement Extracellular medicine DNA origami Humans Pharmacology biology 010405 organic chemistry Organic Chemistry DNA Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology 0104 chemical sciences Nanostructures Folding (chemistry) medicine.anatomical_structure chemistry Cancer cell Biophysics biology.protein 0210 nano-technology Biotechnology HeLa Cells |
| Zdroj: | Bioconjug Chem |
| ISSN: | 1520-4812 |
| Popis: | Cell motions such as migration and change in cellular morphology are essential activities for multicellular organism in response to environmental stimuli. These activities are a result of coordinated clustering/declustering of integrin molecules at the cell membrane. Here, we prepared DNA origami nanosprings to modulate cell motions by targeting the clustering of integrin molecules. Each nanospring was modified with arginyl-glycyl-aspartic acid (RGD) domains with a spacing such that when the nanospring is coiled, the RGD ligands trigger the clustering of integrin molecules, which changes cell motions. The coiling or uncoiling of the nanospring is controlled, respectively, by the formation or dissolution of an i-motif structure between neighboring piers in the DNA origami nanodevice. At slightly acidic pH ( |
| Databáze: | OpenAIRE |
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