Prevalence of Drug-Resistant Tuberculosis in Sudan: A Systematic Review and Meta-Analysis
| Autor: | Asiful Islam, Mubarak Ibrahim Idriss, Mahfuza Marzan, Khalid Hajissa |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty antibiotic resistance Tuberculosis drug-resistant prevalence 030106 microbiology RM1-950 Drug resistance Biochemistry Microbiology Article Sudan 03 medical and health sciences 0302 clinical medicine Antibiotic resistance systematic review Internal medicine Epidemiology medicine Pharmacology (medical) 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics business.industry Isoniazid medicine.disease meta-analysis Infectious Diseases tuberculosis Streptomycin Meta-analysis epidemiology Therapeutics. Pharmacology business Rifampicin medicine.drug |
| Zdroj: | Antibiotics Volume 10 Issue 8 Antibiotics, Vol 10, Iss 932, p 932 (2021) |
| ISSN: | 2079-6382 |
| DOI: | 10.3390/antibiotics10080932 |
| Popis: | Drug-resistant tuberculosis (DR-TB) is still one of the most critical issues impeding worldwide TB control efforts. The aim of this systematic review and meta-analysis was to give an updated picture of the prevalence of DR-TB in Sudan. A comprehensive systematic search was performed on four electronic databases (PubMed, Scopus, Web of Science and Google Scholar) to identify all published studies reporting prevalence data of DR-TB in Sudan. Sixteen eligible studies published during 2002–2020 were included. Using meta-analysis of proportions, the pooled prevalence of TB cases with resistance to any anti-TB drugs was 47.0% (95% CI: 35.5–58.6%). The overall prevalence of mono, multi, poly and extensive drug resistance were estimated to be 16.2% (95% CI: 9.0–23.4%), 22.8% (95% CI: 16.0–29.7%), 6.8% (95% CI: 0.5–13.0%) and 0.7% (95% CI: 0–2.1%), respectively. Considering any first-line anti-TB drugs, the resistance prevalence was highest for isoniazid (32.3%) and streptomycin (31.7%), followed by rifampicin (29.2%). In contrast, resistance against second-line drugs was reported for only two antibiotics, namely, ofloxacin (2.1%) and kanamycin (0.7%). Of note, the resistance profile of the previously treated patients was found to be remarkably high compared with the newly diagnosed TB patients. The relatively high prevalence estimation of anti-TB drug resistance warrants strengthening TB control and treatment strategies in Sudan. |
| Databáze: | OpenAIRE |
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