Association between lipoprotein(a) and progression of coronary artery disease in middle-aged men
| Autor: | Michael Schoeppenthau, Ekkehard Scheffler, Gerhard Schuler, Rainer Hambrecht, Klaus Hauer, Christian Marburger, Josef Niebauer, Guenter Schlierf |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Blood lipids Coronary Disease Physical exercise Coronary artery disease Internal medicine medicine Humans Myocardial infarction Exercise Coronary atherosclerosis biology business.industry Lipoprotein(a) Middle Aged Prognosis medicine.disease Middle age Surgery biology.protein Cardiology Cardiology and Cardiovascular Medicine business Lipoprotein |
| Zdroj: | The American Journal of Cardiology. 73:742-746 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/0002-9149(94)90874-5 |
| Popis: | The association between lipoprotein(a) (Lp[a]) and progression of coronary artery disease (CAD) compared with other serum lipids was evaluated in 104 patients with angiographically proven coronary atherosclerosis. Patients were randomized to either an intervention or a control group. The 12-month intervention program consisted of a low-fat diet and daily physical exercise. Patients in the control group received "usual care" by their private physician. Eighty-three patients (36 in the intervention and 47 in the control group) underwent repeat angiography after 1 year. Angiographically documented net regression was seen in 13 patients (8 in the intervention and 5 in the control group), no change was seen in 40 patients (21 in the intervention and 19 in the control group) and progression was noted in 30 patients (7 in the intervention and 23 in the control group). No correlation could be shown between Lp(a) and angiographically documented progression of the disease. In a multivariate analysis including metabolic variables, group assignment, age and smoking habits, only assignment to the intervention group (p = 0.0075) and a decrease in total cholesterol (p = 0.0167) were independently associated with the course of the disease. Patients with or without previous myocardial infarction (70 vs 34) did not differ in Lp(a) levels (median 9.15 vs 14.25 mg/dl). Patients with Lp(a)25 mg/dl were younger than patients with Lp(a)or = 25 mg/dl (52 vs 55 years; p0.03), indicating a connection between Lp(a) and the development of premature CAD.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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