Is Acanthosis Nigricans a Marker of Insulin Resistance in Obese Children?
| Autor: | Claudio Gonzalez, Valeria Hirschler, Claudio Aranda, Adriana Oneto, Mauricio Jadzinsky |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Argentina Type 2 diabetes Insulin resistance Diabetes mellitus Internal medicine Odds Ratio Internal Medicine medicine Humans Insulin Family IGFBP1 Acanthosis Nigricans Obesity Risk factor Child Acanthosis nigricans Advanced and Specialized Nursing business.industry Glucose Tolerance Test medicine.disease Endocrinology Diabetes Mellitus Type 2 Insulin Resistance business Biomarkers Homeostasis |
| Zdroj: | Diabetes Care. 25:2353-2353 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/diacare.25.12.2353 |
| Popis: | Acanthosis nigricans (AN) was proposed as an insulin resistance marker and an independent risk factor for type 2 diabetes (1). A number of studies had associated AN with insulin resistance (IR) and much higher prevalence of type 2 diabetes in childhood. (2) Although children with AN are often obese, only few studies have considered the roles of BMI and AN as independent markers of IR. The purpose of this research was to compare several indexes of IR (i.e., homeostasis model assessment of IR [HOMA-IR], insulin-like growth factor binding protein 1 [IGFBP1] levels, and base insulinemia) in obese children with and without AN and to determine the rate of association between AN and BMI, HDL, triglycerides, and other predictors of type 2 diabetes. A total … |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|