Small intestinal transit, absorption, and permeability in patients with AIDS with and without diarrhoea
| Autor: | Ingvar Bjarnason, Chris Taylor, P Neild, Brian Gazzard, D Sharpstone, R Sherwood, C Hodgson, Roger Crane |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Diarrhea medicine.medical_specialty Malabsorption Cryptosporidiosis Cytomegalovirus colitis Gastroenterology Permeability Article Intestinal absorption Lactulose Crohn Disease Weight loss Internal medicine Intestine Small Microsporidiosis medicine Humans Gastrointestinal Transit Acquired Immunodeficiency Syndrome Intestinal permeability AIDS-Related Opportunistic Infections Gastric emptying business.industry digestive oral and skin physiology Reproducibility of Results Middle Aged medicine.disease Gastric Emptying Intestinal Absorption medicine.symptom business medicine.drug |
| Zdroj: | Gut. 45:70-76 |
| ISSN: | 0017-5749 |
| DOI: | 10.1136/gut.45.1.70 |
| Popis: | BACKGROUND—Diarrhoea in AIDS is associated with anorexia and weight loss. The importance of gastrointestinal transit in such symptoms has not been addressed. AIMS—To assess jejunal to caecal transit times in subjects with AIDS related diarrhoea and weight loss and correlate these with measures of absorptive capacity and intestinal permeability. METHODS—Jejunal to caecal transit times were assessed in 20 seronegative controls and 60 HIV seropositive subjects from serum analysis of 3-O-methyl-D-glucose and sulphapyridine after ingestion of the monosaccharide and sulphasalazine in aqueous solution. The method also allows an estimation of gastric emptying times for liquids. Intestinal absorptive capacity and permeability were assessed by a combined test using 3-O-methyl-D-glucose, D-xylose, L-rhamnose, and lactulose. RESULTS—Gastric emptying was significantly delayed in all groups of patients with AIDS. Mean jejunal to caecal transit times were not significantly different between controls (246 (62) minutes) and patients without diarrhoea (AIDS, well: 278 (103) minutes; AIDS, wasting: 236 (68) minutes), cytomegalovirus colitis (289 (83) minutes), pathogen negative diarrhoea (192 (100) minutes), or microsporidiosis (190 (113) minutes), although 30% of patients had values below the control range. Patients with cryptosporidiosis differed significantly from controls (135 (35) minutes, p |
| Databáze: | OpenAIRE |
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