Pseudothrombocytopenia and IgA-Related Platelet Agglutinin in a Patient with IgA Nephritis
| Autor: | Yasushi Nakamoto, Tsuyoshi Miyakuni, Akira Miura, Kazunobu Miki, Hirokazu Imai |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
Blood Platelets Nephritis medicine.diagnostic_test biology business.industry medicine.disease Thrombocytopenia Immunoglobulin A Glomerulonephritis Agglutinin Agglutinins Mesangium Pseudothrombocytopenia Immunology medicine biology.protein Humans Mesangial proliferative glomerulonephritis Female Platelet Renal biopsy Antibody business |
| Zdroj: | Nephron. 34:154-158 |
| ISSN: | 2235-3186 1660-8151 |
| Popis: | A 41-year-old female was evaluated for asymptomatic proteinuria and thrombocytopenia. The renal biopsy disclosed mild to moderate mesangial proliferation, and the immunohistology showed granular deposition of dominant IgA and C3 in the mesangium, which is consistent with IgA nephritis. Thrombocytopenia was EDTA-dependent pseudothrombocytopenia type 1. Heparinized blood restored the platelet count to normal. Serological examinations revealed that the platelet agglutinin was IgA, and the platelet clumping required both EDTA and IgA-related agglutinin. Thus, the present case adds the combination of IgA nephritis and pseudothrombocytopenia to the spectrum of the so-called thromborenal syndrome. In view of recent findings that platelet agglutinins belong to immunoglobulins or fractions, occurring frequently in a variety of immunologically abnormal situations, IgA-related agglutinin as seen in this patient may have more than a chance association with IgA nephritis. |
| Databáze: | OpenAIRE |
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