Preparation of homoallylic amines via a three-component coupling process

Autor:	Ricardo Labes, Steven V. Ley, Claudio Battilocchio, Xiaoxu Ou
Rok vydání:	2018
Předmět:	chemistry.chemical_compound 010405 organic chemistry Chemistry Component (thermodynamics) Organic Chemistry Organic chemistry Physical and Theoretical Chemistry Trimethylsilyldiazomethane 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences
Zdroj:	Organic & Biomolecular Chemistry. 16:6652-6654
ISSN:	1477-0539 1477-0520
DOI:	10.1039/c8ob01831f
Popis:	A three-component synthesis of homoallylic amines is described. The allylboronic species were generated in situ by homologation of vinyl boroxines with trimethylsilyldiazomethane, then followed by trapping of the allylboron intermediate with imines. Twenty-seven compounds were successfully prepared in moderate to high yields. Imines bearing various functional groups were tolerated, including aliphatic, aromatic and heteroaromatic substituents. Further elaboration of some of the homoallylic amines to form azeditines is also reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150d872c7ffed2b097ac22fc66f893a3 https://doi.org/10.1039/c8ob01831f Zobrazit plný text záznamu