Obligate basal cell component in salivary oncocytoma facilitates distinction from acinic cell carcinoma
| Autor: | Stephan Ihrler, Thomas Kirchner, Pamela Zengel, Christoph Weiler, Simone Reu |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adenoma Biology Stain Pathology and Forensic Medicine Acinic cell carcinoma Diagnosis Differential Basal (phylogenetics) Predictive Value of Tests Biomarkers Tumor medicine Carcinoma Adenoma Oxyphilic Humans Oncocytoma Aged Aged 80 and over Carcinoma Acinar Cell Tumor Suppressor Proteins Keratin-6 Cell Biology Middle Aged Salivary Gland Neoplasms medicine.disease Immunohistochemistry stomatognathic diseases Trans-Activators Keratin-5 Female Differential diagnosis Transcription Factors |
| Zdroj: | Pathology - Research and Practice. 205:838-842 |
| ISSN: | 0344-0338 |
| DOI: | 10.1016/j.prp.2009.06.019 |
| Popis: | The differential diagnosis between benign salivary oncocytoma (ONC) and low-grade malignant acinic cell carcinoma (ACC) can be difficult due to a significant histomorphological overlap of the structural and cytological presentation of both tumor types. To the best of our knowledge a comprehensive study comparing (immuno-)histological markers in cases of difficult differential diagnosis between ONC and ACC has not yet been performed. We investigated a panel of different immunohistochemical (CK5/6, CK14, CK7, CK18, p63 and Ki67) and histochemical (PAS, alpha-amylase) markers in 12 cases of ONC and 19 cases of ACC. The statistically significant stronger expression of CK7 in ONC and stronger expression of PAS and alpha-amylase in ACC in routine practice each is hampered by a pronounced overlap between both tumor groups. The obligate presence of an additional small basal cell component in all cases of ONC, demonstrable with p63 and CK5/6, enables a straightforward distinction from ACC, being constantly devoid of a basal cell component. Unexpectedly, CK14 is not a suitable marker for a reliable proof of these basal cells. The detection of this basal cell component in ONC in routine Hematoxylin-eosin stain is difficult and in some cases not possible; therefore, immunohistochemistry with p63 or CK5/6 is recommended for selected cases. |
| Databáze: | OpenAIRE |
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