Human herpesvirus 8-encoded interleukin-6 homologue (viral IL-6) induces endogenous human IL-6 secretion
| Autor: | Yasuko Mori, Kazuyuki Yoshizaki, Panadda Dhepakson, Kiyoko Amou, Koichi Yamanishi, Reiko Inagi, Mika Ohno, Norihiro Nishimoto |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_treatment
Lymphocyte Endogeny Biology medicine.disease_cause Herpesviridae Cell Line Mice Viral Proteins Virology medicine Gammaherpesvirinae Animals Humans Secretion Interleukin 6 Sarcoma Kaposi Interleukin-6 Castleman Disease Herpesviridae Infections biology.organism_classification Infectious Diseases Cytokine medicine.anatomical_structure Cell culture Herpesvirus 8 Human biology.protein |
| Zdroj: | Journal of medical virology. 61(3) |
| ISSN: | 0146-6615 |
| Popis: | We found that human herpesvirus 8-encoded IL-6 (vlL-6) induced endogenous human IL-6 (hulL-6) secretion from various cell lines (MT-4, THP-1, U937, Raji, and CESS) including patients with multicentric Castleman's disease. Especially, in MT-4 cells, hulL-6 was enhanced with vlL-6 by 30-fold compared with that of control. In addition, reverse transcriptase-polymerase chain reaction confirmed that vlL-6 induced hulL-6 expression in MT-4 cells. Our novel finding of the hulL-6 induction by vlL-6 indicates that vlL-6 may play a significant role in the pathogenesis of HHV-8 associated diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text