Dynamics of Poly(ethylene glycol)-Tethered, pH Responsive Networks
| Autor: | James W. McGinity, J. Brock Thomas, Joseph H. Tingsanchali, Nicholas A. Peppas, Courtney M. Creecy, Adrianne M. Rosales |
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| Rok vydání: | 2008 |
| Předmět: |
Poly(methacrylic acid)
Materials science Polymers and Plastics Organic Chemistry technology industry and agriculture pH-sensitive polymers Polyelectrolyte Article chemistry.chemical_compound chemistry Polymer chemistry PEG ratio Materials Chemistry Precipitation polymerization Drug carrier Ethylene glycol Acrylic acid |
| Zdroj: | Polymer. 48(17) |
| ISSN: | 0032-3861 |
| Popis: | Smart biomaterials composed of pH responsive polymers, poly((meth)acrylic acid), were synthesized using a precipitation polymerization technique. The microparticles were grafted with poly(ethylene glycol) (PEG) chains that are capable of complexing with the hydroxyl groups of the polyacid and interpenetrating into the mucus gel layer upon entry into the small intestine. Upon introduction of an alkaline solution, these materials imbibe a significant amount of water and create a highly viscous suspension. These materials have the necessary physicochemical properties to serve as mucoadhesive controlled release drug carriers for the oral delivery of drugs. |
| Databáze: | OpenAIRE |
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