Portable, bedside, low-field magnetic resonance imaging for evaluation of intracerebral hemorrhage
| Autor: | Adrienne Ward, Joseph Schindler, Nils H Petersen, Rachel Beekman, Jonathan M. Rothberg, W. Taylor Kimberly, Jens Witsch, Anjali M. Prabhat, Joseph Antonios, Gordon Sze, Bradley A Cahn, Mercy H Mazurek, Charles R. Wira, Teng J. Peng, Kevin N. Sheth, E. Brian Welch, Matthew M Yuen, Lauren H Sansing, Jennifer A. Kim, David Y. Hwang, Michael Poole, Audrey C Leasure, Kevin T Gobeske, Isha R. Chavva, Nona Timario, Jill T Shah, Charles C. Matouk, Anna L. Crawford, Emily J. Gilmore, Guido J. Falcone, Ajay Malhotra, Matthew S. Rosen, Laura Sacolick |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Science Physics::Medical Physics General Physics and Astronomy Neuroimaging Stroke care Article General Biochemistry Genetics and Molecular Biology Hematoma Humans Medicine cardiovascular diseases Aged Cerebral Hemorrhage Aged 80 and over Intracerebral hemorrhage Multidisciplinary medicine.diagnostic_test business.industry Brain Magnetic resonance imaging General Chemistry Middle Aged Translational research Radiological examination medicine.disease High magnetic field strength equipment and supplies Magnetic Resonance Imaging Stroke Computer Science::Graphics Neurology Female Tomography business Nuclear medicine human activities |
| Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Radiological examination of the brain is a critical determinant of stroke care pathways. Accessible neuroimaging is essential to detect the presence of intracerebral hemorrhage (ICH). Conventional magnetic resonance imaging (MRI) operates at high magnetic field strength (1.5–3 T), which requires an access-controlled environment, rendering MRI often inaccessible. We demonstrate the use of a low-field MRI (0.064 T) for ICH evaluation. Patients were imaged using conventional neuroimaging (non-contrast computerized tomography (CT) or 1.5/3 T MRI) and portable MRI (pMRI) at Yale New Haven Hospital from July 2018 to November 2020. Two board-certified neuroradiologists evaluated a total of 144 pMRI examinations (56 ICH, 48 acute ischemic stroke, 40 healthy controls) and one ICH imaging core lab researcher reviewed the cases of disagreement. Raters correctly detected ICH in 45 of 56 cases (80.4% sensitivity, 95%CI: [0.68–0.90]). Blood-negative cases were correctly identified in 85 of 88 cases (96.6% specificity, 95%CI: [0.90–0.99]). Manually segmented hematoma volumes and ABC/2 estimated volumes on pMRI correlate with conventional imaging volumes (ICC = 0.955, p = 1.69e-30 and ICC = 0.875, p = 1.66e-8, respectively). Hematoma volumes measured on pMRI correlate with NIH stroke scale (NIHSS) and clinical outcome (mRS) at discharge for manual and ABC/2 volumes. Low-field pMRI may be useful in bringing advanced MRI technology to resource-limited settings. Conventional magnetic resonance imaging (MRI) operates at a high magnetic field strength and requires a strict access-controlled environment, making MRI often inaccessible. Here, the authors present a portable low-field MRI device that detects intracerebral hemorrhage with high accuracy. |
| Databáze: | OpenAIRE |
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