Association of N-Linked Glycoprotein Acetyls and Colorectal Cancer Incidence and Mortality
Autor: | Lu Wang, Margery A. Connelly, M. Vinayaga Moorthy, JoAnn E. Manson, Akintunde O. Akinkuolie, Deirdre K Tobias, Chungying Li, I-Min Lee, Julie E. Buring, Paulette D. Chandler, Robert J. Glynn, Samia Mora, Wendy S. Post, James D. Otvos, Patrick R. Lawler, Daniel A. Duprez, David R. Jacobs, Paul M. Ridker |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Oncology Male Glycosylation Glycobiology lcsh:Medicine Fibrinogen Pathology and Laboratory Medicine Biochemistry Risk Factors Medicine and Health Sciences Prospective Studies Post-Translational Modification Prospective cohort study lcsh:Science Immune Response Multidisciplinary Incidence (epidemiology) Incidence Middle Aged Prognosis 3. Good health Survival Rate C-Reactive Protein Cohort Biomarker (medicine) Female Colorectal Neoplasms medicine.drug Research Article medicine.medical_specialty Inflammatory Diseases Immunology 03 medical and health sciences Signs and Symptoms Polysaccharides Diagnostic Medicine Internal medicine medicine Humans Survival rate Aged Glycoproteins Colorectal Cancer Inflammation Proportional hazards model business.industry lcsh:R Case-control study Cancers and Neoplasms Biology and Life Sciences Proteins Acute Phase Proteins United States 030104 developmental biology Case-Control Studies lcsh:Q business Biomarkers Acute-Phase Proteins Follow-Up Studies |
Zdroj: | PLoS ONE, Vol 11, Iss 11, p e0165615 (2016) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | Background Acute phase proteins highlight the dynamic interaction between inflammation and oncogenesis. GlycA, a novel nuclear magnetic resonance (NMR) inflammatory marker that identifies primarily circulating N-acetyl glycan groups attached to acute phase proteins, may be a future CRC risk biomarker. Methods We examined the association between GlycA and incident CRC and mortality in two prospective cohorts (N = 34,320); Discovery cohort: 27,495 participants from Women's Health Study (WHS); Replication cohort: 6,784 participants from Multi-Ethnic Study of Atherosclerosis (MESA). Multivariable Cox models were adjusted for clinical risk factors and compared GlycA to acute phase proteins (high-sensitivity C-reactive protein [hsCRP], fibrinogen, and soluble intercellular adhesion molecule-1 [sICAM-1]). Results In WHS (median follow-up 19 years, 337 cases, 103 deaths), adjusted HRs (95% CIs) per SD increment of GlycA for CRC incidence and mortality were 1.19 (1.06–1.35; p = 0.004) and 1.24 (1.00–1.55; p = 0.05), respectively. We replicated findings in MESA (median follow-up 11 years, 70 cases, 23 deaths); HRs (95% CIs) per SD of GlycA for CRC incidence and mortality were 1.32 (1.06–1.65; p = 0.01) and 1.54 (1.06–2.23; p = 0.02), respectively, adjusting for age, sex, and race. Pooled analysis, adjusted HR (95% CI) per SD of GlycA for CRC incidence and mortality was 1.26 (1.15–1.39; p = 1 x 10−6). Other acute phase proteins (hsCRP, fibrinogen, and sICAM-1) had weaker or no association with CRC incidence, while only fibrinogen and GlycA were associated with CRC mortality. Conclusions The clinical utility of GlycA to personalize CRC therapies or prevention warrants further study. Trial Registration ClinicalTrials.gov: WHS NCT00000479, MESA NCT00005487 |
Databáze: | OpenAIRE |
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