Ultrasound-mediated disruption of the blood tumor barrier for improved therapeutic delivery

Autor: Samuel A. Sprowls, W. Pentz, Manish Ranjan, A. Gabriele, Brooke N. Kielkowski, Jeffrey S Carpenter, Pushkar Saralkar, Rashi I. Mehta, Paul R. Lockman, Ross Fladeland, Peng Wang, Tasneem Arsiwala, Chris E. Adkins, Kathryn E Blethen, Ali R. Rezai, Umer Najib
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
DAMP
Damage associated molecular pattern
Cancer Research
MRI
Magnetic resonance imaging
Focused ultrasound
medicine.medical_treatment
GBM
Glioblastoma
Ultrasonic Therapy
Review Article
0302 clinical medicine
Drug Delivery Systems
Tumor Microenvironment
Medicine
Neoplasm Metastasis
RC254-282
Blood-brain barrier
VEGF
Vascular Endothelial Growth Factor
CNS
Central nervous system
Brain Neoplasms
ABC
ATP-binding cassette
Ultrasound
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
BCRP
Breast cancer resistant protein
ABCG2
BBB
Blood-brain barrier
medicine.anatomical_structure
HIFU
High intensity focused ultrasound
Treatment Outcome
Ultrasonic Waves
030220 oncology & carcinogenesis
Drug delivery
cardiovascular system
P-gp
P-glycoprotein
ABCB1
Central nervous system
Blood–brain barrier
Permeability
LIFU
Low-intensity focused ultrasound
03 medical and health sciences
DCE
Dynamic contrast enhancement
HLA
Human Leukocyte antigen
Blood-tumor barrier
Animals
Humans
FUS
Focused ultrasound
Chemotherapy
Tumor microenvironment
MRP
Multi-drug resistant protein
ABCC1
business.industry
Blood tumor barrier
TNF
Tumor necrosis factor
Biological Transport
AUC
Area under the curve
Disease Models
Animal
030104 developmental biology
Biological Variation
Population
BTB
Blood-tumor barrier
Cancer research
Disruption
High-Intensity Focused Ultrasound Ablation
business
Zdroj: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 7, Pp 676-691 (2021)
ISSN: 1476-5586
1522-8002
Popis: The blood-brain barrier (BBB) is a major anatomical and physiological barrier limiting the passage of drugs into brain. Central nervous system tumors can impair the BBB by changing the tumor microenvironment leading to the formation of a leaky barrier, known as the blood-tumor barrier (BTB). Despite the change in integrity, the BTB remains effective in preventing delivery of chemotherapy into brain tumors. Focused ultrasound is a unique noninvasive technique that can transiently disrupt the BBB and increase accumulation of drugs within targeted areas of the brain. Herein, we summarize the current understanding of different types of targeted ultrasound mediated BBB/BTB disruption techniques. We also discuss influence of the tumor microenvironment on BBB opening, as well as the role of immunological response following disruption. Lastly, we highlight the gaps between evaluation of the parameters governing opening of the BBB/BTB. A deeper understanding of physical opening of the BBB/BTB and the biological effects following disruption can potentially enhance treatment strategies for patients with brain tumors.
Databáze: OpenAIRE
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