Consumption of differently processed milk products in infancy and early childhood and the risk of islet autoimmunity

Autor: Hanna-Mari Takkinen, Mikael Knip, Jaakko Nevalainen, Tuuli E. Korhonen, Jaakko Peltonen, Jorma Toppari, Sari Niinistö, Essi Syrjälä, Tapani Alatossava, Suvi Ahonen, Jorma Ilonen, Mari Akerlund, Suvi M. Virtanen, Katariina Koivusaari, Riitta Veijola
Přispěvatelé: Tampere University, Computing Sciences, Health Sciences, Department of Paediatrics, Tays Research Services, Department of Food and Nutrition, University of Helsinki, HUS Children and Adolescents, Children's Hospital, Helsinki University Hospital Area, Helsinki Institute of Sustainability Science (HELSUS), Tapani Alatossava / Principal Investigator, Food Sciences
Rok vydání: 2020
Předmět:
YOUNG-CHILDREN
HOMOGENIZATION
030309 nutrition & dietetics
Population
Medicine (miscellaneous)
Physiology
Pasteurization
030209 endocrinology & metabolism
IMMUNOGENICITY
3121 Internal medicine
Heat treatment
law.invention
Joint models
03 medical and health sciences
0302 clinical medicine
law
Fermented milk products
Homogenisation
Medicine
PASTEURIZATION
Risk factor
education
Prospective cohort study
Children
Islet autoimmunity
2. Zero hunger
FORMULA
0303 health sciences
education.field_of_study
geography
Type 1 diabetes
Nutrition and Dietetics
geography.geographical_feature_category
TYPE-1 DIABETES-MELLITUS
business.industry
Hazard ratio
food and beverages
Milk products
Survival analysis
Islet
medicine.disease
GENOTYPE
SIBLINGS
3141 Health care science
AUTOANTIBODIES
3143 Nutrition
business
Zdroj: British Journal of Nutrition. 124:173-180
ISSN: 1475-2662
0007-1145
DOI: 10.1017/s0007114520000744
Popis: Several prospective studies have shown an association between cows’ milk consumption and the risk of islet autoimmunity and/or type 1 diabetes. We wanted to study whether processing of milk plays a role. A population-based birth cohort of 6081 children with HLA-DQB1-conferred risk to type 1 diabetes was followed until the age of 15 years. We included 5545 children in the analyses. Food records were completed at the ages of 3 and 6 months and 1, 2, 3, 4 and 6 years, and diabetes-associated autoantibodies were measured at 3–12-month intervals. For milk products in the food composition database, we used conventional and processing-based classifications. We analysed the data using a joint model for longitudinal and time-to-event data. By the age of 6 years, islet autoimmunity developed in 246 children. Consumption of all cows’ milk products together (energy-adjusted hazard ratio 1·06; 95 % CI 1·02, 1·11; P = 0·003), non-fermented milk products (1·06; 95 % CI 1·01, 1·10; P = 0·011) and fermented milk products (1·35; 95 % CI 1·10, 1·67; P = 0·005) was associated with an increased risk of islet autoimmunity. The early milk consumption was not associated with the risk beyond 6 years. We observed no clear differences based on milk homogenisation and heat treatment. Our results are consistent with the previous studies, which indicate that high milk consumption may cause islet autoimmunity in children at increased genetic risk. The study did not identify any specific type of milk processing that would clearly stand out as a sole risk factor apart from other milk products.
Databáze: OpenAIRE
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