The effect of angiotensin converting enzyme inhibition on effective renal plasma flow in patients with diffuse renal parenchymal diseases and hypertension
| Autor: | Romana Mijovic, Radmila Zeravica, Zoran Stošić, Branislava Ilincic, Ana Jakovljevic, Veljko Crnobrnja |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Urology Renal function Angiotensin-Converting Enzyme Inhibitors PAH clearance urologic and male genital diseases Essential hypertension Kidney Internal medicine medicine Humans biology business.industry Hemodynamics Angiotensin-converting enzyme Captopril General Medicine Effective renal plasma flow Middle Aged medicine.disease Renal Plasma Flow Effective medicine.anatomical_structure Endocrinology Renal blood flow Hypertension biology.protein Kidney Diseases Essential Hypertension business medicine.drug |
| Zdroj: | Medicinski pregled. 67(3-4) |
| ISSN: | 0025-8105 |
| Popis: | Introduction. Angiotensin converting enzyme inhibitors are commonly used to treat various hypertensive conditions and in addition to lowering blood pressure these drugs affect the local renal hemodynamic status, thereby influencing the glomerular filtration rate and effective renal plasma flow. The study was aimed at determining whether angiotensin converting enzyme inhibitors can produce significant changes in effective renal plasma flow in patients with parenchymal renal disease and to assess whether the changes depend on the pre-existing functional status of the kidney. Material and Methods. The study included 80 subjects, 40 subjects with hypertension associated with diffuse renal parenchymal disease and 40 subjects with essential hypertension. All study subjects underwent the baseline effective renal plasma flow measurement and the repeated effective renal plasma flow measurement after administration of captopril. Effective renal plasma flow was determined by 131 I-hippuran clearance in blood samples taken at 20 and 30 minutes. Results. Angiotensin converting enzyme inhibitors caused significant effective renal plasma flow changes in 55% of subjects with diffuse renal parenchymal disease and in 75% of subjects with essential hypertension. The effective renal plasma flow changes were more significant in subjects with preserved renal function (normal baseline effective renal plasma flow) compared to subjects with reduced baseline effective renal plasma flow. Conclusion. The application of angiotensin converting enzyme inhibitors in patients with diffuse renal parenchymal disease and in individuals with essential hypertension may result in significant hemodynamic changes in the kidney, accompanied by changes in effective renal plasma flow. The extent of the changes caused by angiotensin converting enzyme inhibitors depends on the preexisting functional status of the kidney. |
| Databáze: | OpenAIRE |
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