Increased Serum Acylated Ghrelin Levels in Patients with Mild Cognitive Impairment
| Autor: | Yifeng Du, Min Zhu, Yan He, Wenzheng Chu, Xi Cao, Heng Du |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Disease Article 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Risk Factors Internal medicine Orexigenic Hyperlipidemia medicine Humans Cognitive Dysfunction 030212 general & internal medicine Aged business.industry General Neuroscience digestive oral and skin physiology Cognition General Medicine Middle Aged medicine.disease Ghrelin Stimulant Psychiatry and Mental health Clinical Psychology Endocrinology Case-Control Studies Biomarker (medicine) Female Geriatrics and Gerontology business Biomarkers hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Hormone medicine.drug |
| Zdroj: | Journal of Alzheimer's Disease. 61:545-552 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-170721 |
| Popis: | Ghrelin is a stomach-derived circulating hormone. In addition to its function as an orexigenic stimulant, the role of ghrelin in the consolidation of learning and memory has been implicated in recent years. However, the status of circulating acylated ghrelin (AG, that is, the functional form of ghrelin) in the symptomatic predementia stage of Alzheimer’s disease (AD) has rarely been investigated. In the current study, we examined the serum levels of acylated and total ghrelin in 22 patients with mild cognitive impairment (MCI) and 30 cognitively normal controls. We have found that patients with MCI had significantly increased serum AG levels, which were inversely associated with defected short- and long-term memory as well as language skills. Of note, the levels of total circulating ghrelin were similar between the two groups. Intriguingly, serum AG but not total ghrelin was associated with AD risk factors including the age, hypertension, and hyperlipidemia. Therefore, circulating AG may serve as a potential early systemic biomarker for AD-related cognitive impairments. Nevertheless, the simplest interpretation of the results is that the levels of circulating AG are associated with cognitive impairments in patients with MCI, thereby forming the groundwork for our future studies on the systemic mechanisms of AD pertaining to the ghrelin system. |
| Databáze: | OpenAIRE |
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