Enterococcus faecalis milk fermentates display antioxidant properties and inhibitory activity towards key enzymes linked to hypertension and hyperglycaemia
| Autor: | P.J. Simpson, Helena Stack, Rosemary Rea, Ken Graham |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Antioxidant DPPH medicine.medical_treatment Bioactive milk products Medicine (miscellaneous) α-Glucosidase inhibition Enterococcus faecalis Antioxidants 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology medicine TX341-641 Food science Milk fermentation chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics biology Nutrition. Foods and food supply food and beverages Angiotensin-converting enzyme 04 agricultural and veterinary sciences ACE inhibition biology.organism_classification 040401 food science In vitro Enzyme chemistry biology.protein Fermentation Trolox Food Science |
| Zdroj: | Journal of Functional Foods, Vol 58, Iss, Pp 292-300 (2019) |
| ISSN: | 1756-4646 |
| Popis: | In this study, Enterococcus faecalis milk fermentates were assayed for total phenolic content, related antioxidant activity and the inhibition of key enzymes linked to hypertension and hyperglycaemia. Of the 25 isolates, milk fermented with E. faecalis DPC5154 had the highest level of total phenolic compounds (739.06 µg GAE/ml) and demonstrated the highest level of Trolox Equivalent Antioxidant Activity (TEAA) based on DPPH radical scavenging activity and ferric reducing antioxidant power (271.27 TEAA (µM) and 272.75 TEAA (µM), respectively). Inhibition of Angiotensin Converting Enzyme (ACE) and α-glucosidase is considered a useful therapeutic approach in the management of hypertension and hyperglycaemia, respectively. Milk fermented with DPC5154 completely inhibited ACE and displayed the highest level of α-glucosidase inhibitory activity (33.41%). These studies provide in vitro evidence for the beneficial use of DPC5154 and other E. faecalis isolates for the generation of bioactive milk products with antioxidant, antihypertensive and anti-hyperglycaemic activity. |
| Databáze: | OpenAIRE |
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