Nicotinic acetylcholine receptor stimulation: A new approach for stimulating tear secretion in dry eye disease

Autor:	Stephen C. Pflugfelder, Austin Cao, Anat Galor, Kelly K. Nichols, Noam A. Cohen, Michelle Dalton
Rok vydání:	2022
Předmět:	Ophthalmology Tears Lacrimal Apparatus Humans Nociceptors Dry Eye Syndromes Receptors Nicotinic
Zdroj:	The Ocular Surface. 25:58-64
ISSN:	1542-0124
DOI:	10.1016/j.jtos.2022.05.001
Popis:	Tear secretion is regulated by the lacrimal functional unit consisting of afferent and efferent nerve innervation. The afferent arm consists of trigeminal nociceptors on the ocular surface and nasal mucosa. When stimulated by agonists, nicotinic acetylcholine receptors on nerve endings in the nose initiate a reflex arc resulting in instantaneous tear secretion. Pharmacologic nasal neural stimulation to increase endogenous tear production is a novel approach to treating dry eye disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148de3b3ca0fb6ff0a7570ebda276908 https://doi.org/10.1016/j.jtos.2022.05.001 Zobrazit plný text záznamu Full Text from ScienceDirect