RATE OF DISSOLUTION OF DIGOXIN TABLETS AS A PREDICTOR OF ABSORPTION

Autor:	Carole Bye, BrianF. Johnson, John Mccrerie, Arthur Fowle, Hugh Greer
Rok vydání:	1973
Předmět:	Digoxin Time Factors Chemistry General Medicine Absorption (skin) Pharmacology Biopharmaceutics Urinary excretion Animal science Intestinal Absorption Solubility Healthy volunteers Plasma concentration medicine Humans Dissolution Tablets medicine.drug
Zdroj:	The Lancet. 301:1473-1475
ISSN:	0140-6736
DOI:	10.1016/s0140-6736(73)91811-4
Popis:	Five experimental batches of 0·25 mg. tablets demonstrated large differences in the rate of dissolution of their digoxin content in a described apparatus. In twenty healthy volunteers, following treatment periods of one tablet every 12 hours for 14 days, plasma-digoxin concentration and urinary excretion were significantly correlated with tablet-dissolution rate. Mean plasma concentration ranged from 1·07 ng. per ml. on tablets of the lowest dissolution-rate to 1·49 ng. per ml. on those of the highest dissolution-rate. Similarly, mean urinary excretion ranged from 86 to 146 μg. per dosage interval. It is suggested that a minimal acceptable level of dissolution-rate be established for digoxin tablets.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148bbe5c6b2d4fc53ac9a8a996b1d6fc https://doi.org/10.1016/s0140-6736(73)91811-4 Zobrazit plný text záznamu