Thyroxine augmentation of growth hormone-induced endochondral osteogenesis
| Autor: | Asling Cw, Riekstniece E |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
Pituitary growth hormone
medicine.medical_specialty Tibia Chemistry Epiphyseal plate Drug Synergism Growth hormone General Biochemistry Genetics and Molecular Biology Rats Thyroxine medicine.anatomical_structure Endocrinology Cartilage Osteogenesis Internal medicine Growth Hormone medicine Thyroidectomy Animals Endochondral ossification Epiphyses Hormone Hypophysectomy |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 123(1) |
| ISSN: | 0037-9727 |
| Popis: | SummaryThe possibility has been investigated that thyroxine is required to support the chondrogenetic effects of growth hormone in endochondral osteogenesis. Effects of these hormones have been determined in hypophy-sectomized, thyroidectomized, and hypophy-sectomized-thyroidectomized rats, being measured by the tibial epiphyseal plate widening response commonly employed in growth hormone assay. A dose of 1-thyroxine lying between 0.25 and 0.5 μg/day (a) restored vigorous endochondral osteogenesis in thyroidecto-mized rats, (b) increased their pituitary growth hormone content to normal, and (c) in hypophysectomized-thyroidectomized rats augmented the effect of a dose of growth hormone to equal that when the growth hormone dose was given alone to hypophysectomized rats. |
| Databáze: | OpenAIRE |
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