HLA antigens in hemophiliacs A with or without factor VIII antibodies in a Venezuelan Mestizo population
| Autor: | E. Garcia, Zulay Layrisse, N. De Bosch, A. Argueyo, N. Simonney |
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| Rok vydání: | 2008 |
| Předmět: |
musculoskeletal diseases
Immunology Population Human leukocyte antigen Hemophilia A Biochemistry Antibodies Gene Frequency Antigen HLA Antigens Healthy control HLA-DR4 Antigen Genetics Coagulopathy medicine Humans Immunology and Allergy skin and connective tissue diseases education education.field_of_study Factor VIII biology business.industry Significant difference Histocompatibility Antigens Class II General Medicine Venezuela medicine.disease Virology Immunization biology.protein Antibody business |
| Zdroj: | Tissue Antigens. 25:216-219 |
| ISSN: | 1399-0039 0001-2815 |
| DOI: | 10.1111/j.1399-0039.1985.tb00440.x |
| Popis: | Twenty-eight unrelated hemophilia A patients, seven of them with anti-factor VIII antibodies were typed for HLA-A, B, C antigens and 25 of them for HLA-DR. The results show a significant difference in HLA-DR4 frequency between hemophiliacs with antibodies who lack this antigen and hemophiliacs without antibodies, in whom HLA-DR4 is increased as compared to a healthy control series. This data suggests that DR4 may be associated with a factor preventing anti-factor VIII immunization. |
| Databáze: | OpenAIRE |
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