Drug-eluting balloon angioplasty for in-stent restenosis: a systematic review and meta-analysis of randomised controlled trials
| Autor: | Georg M Froehlich, Alexandra J. Lansky, Rahul Bahl, Andreas Indermuehle, Guido Knapp, Adam Timmis, Pascal Meier |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Context (language use) 030204 cardiovascular system & hematology Balloon Coronary Angiography Prosthesis Design Coronary Restenosis 03 medical and health sciences 0302 clinical medicine Restenosis Internal medicine Angioplasty Medicine Humans cardiovascular diseases 030212 general & internal medicine Myocardial infarction Angioplasty Balloon Coronary Randomized Controlled Trials as Topic Interventional cardiology business.industry Stent Drug-Eluting Stents medicine.disease 3. Good health Surgery Treatment Outcome Cardiology Cardiology and Cardiovascular Medicine business Mace |
| Zdroj: | Heart (British Cardiac Society) |
| DOI: | 10.1136/heartjnl-2012-302945 |
| Popis: | CONTEXT The optimal treatment option for in stent restenosis is currently unclear. OBJECTIVE Systematic review and meta analysis of the effect of drug eluting balloons (DEB) to treat in stent restenosis. DATA SOURCES Trials were identified through a literature search from 2005 through 7 November 2012. STUDY SELECTION Randomised clinical trials comparing DEB with a control treatment (plain balloon angioplasty or drug eluting stents). DATA EXTRACTION AND SYNTHESIS Main endpoints of interest were major adverse cardiac events (MACE) target lesion revascularisation (TLR) binary in segment restenosis stent thrombosis (ST) myocardial infarction (MI) and mortality. A random effects model was used to calculate the pooled relative risks (RR) with 95 CIs. RESULTS Five studies and a total of 801 patients were included in this analysis. Follow up duration ranged from 12 to 60months. Most endpoints were significantly reduced for DEB compared with the control groups. For MACE the relative risk RR was 0.46 (0.31 to 0.70) p |
| Databáze: | OpenAIRE |
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