Acute effect of experimental truncal vagotomy on serum gastrin concentrations
| Autor: | S K Lee, Mark Feldman, R C Thirlby, William R. Thompson, J H Walsh |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Gastric Fistula
medicine.medical_specialty Time Factors medicine.medical_treatment Stimulation Acute effect digestive system Gastric Acid Dogs Vagotomy Truncal Internal medicine Truncal vagotomy Gastrins medicine Animals Gastrin Denervation business.industry Gastrin Cells digestive oral and skin physiology Vagotomy Serum gastrin Endocrinology Surgery business hormones hormone substitutes and hormone antagonists Research Article |
| Zdroj: | Annals of surgery. 211(2) |
| ISSN: | 0003-4932 |
| Popis: | We studied the acute effect of transthoracic truncal vagotomy or sham vagotomy (control) on fasting serum gastrin concentrations in 22 gastric fistula dogs. A significant (p less than 0.05) decrease in serum gastrin concentration was detectable within 2.5 minutes after truncal vagotomy, and by 120 minutes serum gastrin has decreased to 15 +/- 1 pg/mL in the vagotomy group compared to 28 +/- 3 pg/mL in the control group (p less than 0.001). However by 24 hours after vagotomy, when maximal acid output was reduced by approximately 50%, fasting serum gastrin had increased nearly twofold above control levels in the vagotomy group (p = 0.06) and this increase persisted at day 7 (p less than 0.05). Thus truncal vagotomy had a biphasic effect on serum gastrin concentrations in dogs (acute inhibition followed by stimulation). While the mechanism for the acute fall in gastrin is probably an acute denervation of postganglionic neurons that innervate gastrin cells, the mechanism for the subsequent rise in serum gastrin remains uncertain. |
| Databáze: | OpenAIRE |
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