Proteomic and metabonomic biomarkers for hepatocellular carcinoma: a comprehensive review
| Autor: | Simon D. Taylor-Robinson, Mark Thursz, Elaine Holmes, Torben Kimhofer, Haddy K S Fye |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Proteomics
GAS CHROMATOGRAPHY/MASS SPECTROMETRY Cancer Research Carcinoma Hepatocellular TISSUE METABOLOMICS Review HEPATITIS-C VIRUS Bioinformatics Metabolomics GAMMA-CARBOXY PROTHROMBIN Biomarkers Tumor Advanced disease Carcinoma medicine Humans HUMAN PLASMA Oncology & Carcinogenesis Biomarker discovery Science & Technology SERUM MARKERS business.industry Liver Neoplasms MASS-SPECTROMETRY medicine.disease Oncology Curative treatment POTENTIAL BIOMARKER Hepatocellular carcinoma Early hcc FUCOSYLATED GLYCOPROTEINS CHRONIC LIVER-DISEASES business Life Sciences & Biomedicine 1112 Oncology And Carcinogenesis |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.2015.38 |
| Popis: | Hepatocellular carcinoma (HCC) ranks third in overall global cancer-related mortality. Symptomatic presentation often means advanced disease where potentially curative treatment options become very limited. Numerous international guidelines propose the routine monitoring of those with the highest risk factors for the condition in order to diagnose potential tumourigenesis early. To aid this, the fields of metabonomic- and proteomic-based biomarker discovery have applied advanced tools to identify early changes in protein and metabolite expression in HCC patients vs controls. With robust validation, it is anticipated that from these candidates will rise a high-performance non-invasive test able to diagnose early HCC and related conditions. This review gathers the numerous markers proposed by studies using mass spectrometry and proton nuclear magnetic resonance spectroscopy and evaluates areas of consistency as well as discordance. |
| Databáze: | OpenAIRE |
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