Combinatorial Synthesis of Peptide Arrays with a Laser Printer
| Autor: | Gloria Torralba, Martin Gröning, Stefan Güttler, Volker Lindenstruth, F. Ralf Bischoff, Thomas Felgenhauer, Ines Block, Volker Stadler, Michael Hausmann, Simon Fernandez, Kai König, Klaus Leibe, Mario Beyer, Alexander Nesterov, Frank Breitling, Annemarie Poustka, Rüdiger Pipkorn |
|---|---|
| Přispěvatelé: | Publica |
| Rok vydání: | 2008 |
| Předmět: |
High-throughput screening
Biotechnologie Protein Array Analysis Peptide Catalysis law.invention Peptide Library law Fertigung Amino Acids chemistry.chemical_classification Chemistry Lasers General Chemistry Laser Combinatorial synthesis Combinatorial chemistry Biochip Biochipfertigung Amino acid Laserdrucktechnik Printing Array-Prozessor Peptidarray Peptides medizinische Diagnostik |
| Zdroj: | Angewandte Chemie International Edition. 47:7132-7135 |
| ISSN: | 1521-3773 1433-7851 |
| DOI: | 10.1002/anie.200801616 |
| Popis: | however, thedecodingofpeptidebindersislaborintensive.Furthermore,problematicpeptides,forexample,hydrophobicpeptidesthatbind nonspecifically to any protein, are also synthesizedduringlibrarypreparationbythesemethods.Arrays do not have these drawbacks. The position of agivenpeptideonanarraycorrespondsdirectlytoitssequence,and problematic peptides can be omitted in subsequentarrays. Peptide arrays were first described by Frank, whosespotsynthesisdominatesthefieldbecauseofitsreliabilityandwideapplicability. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text