Natural killer cell activity in families of patients with systemic lupus erythematosus: demonstration of a killing defect in patients
Autor: | Myer R. Salaman, M H Seifert, David A. Isenberg, Amy S. M. Kennell, M. R. J. Green, Maggie Larché |
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Rok vydání: | 2005 |
Předmět: |
Adult
Cytotoxicity Immunologic Male medicine.medical_specialty Adolescent Lymphocyte Immunology Azathioprine Peripheral blood mononuclear cell Severity of Illness Index Natural killer cell Immune tolerance Arthritis Rheumatoid Internal medicine Clinical Studies medicine Immune Tolerance Immunology and Allergy Cytotoxic T cell Humans Lupus Erythematosus Systemic skin and connective tissue diseases Cells Cultured Aged Immunity Cellular Lupus erythematosus business.industry Middle Aged medicine.disease Killer Cells Natural medicine.anatomical_structure Endocrinology Rheumatoid arthritis Antirheumatic Agents Female business medicine.drug |
Zdroj: | Clinical and experimental immunology. 141(1) |
ISSN: | 0009-9104 |
Popis: | Summary Natural killer (NK) cell cytotoxic activity and cell frequency, expressed as a percentage of total lymphocytes, have been determined in peripheral blood mononuclear cells from first-degree relatives of patients with systemic lupus erythematosus (SLE), the patients themselves, a group of rheumatoid arthritis (RA) patients and controls. Low levels of killing activity relative to controls were found in some members of all groups with the extent of depression falling into two ranges. Moderate reductions were seen in female (3/31, 10%) and male (4/14, 29%) relatives of SLE patients, female (12/60, 20%) and male (3/4, 75%) SLE patients and female RA patients (6/17, 35%). A more profound depression of killing activity was confined to other female SLE patients (15/60, 25%). There were strong correlations in all groups between killing activity and percentage of NK cells, but analysis of the ratio of these parameters and studies with purified preparations of NK cells suggest that the reduced activity in SLE frequently involves a defect in the killing capacity of the individual cells in addition to the reduced levels of NK cells. Azathioprine (AZA), which was used in treatment of 12 SLE patients, was invariably associated with low values of killing activity. It appears to substantially reduce the percentage of NK and B cells in an action unconnected with the NK cell abnormalities associated with SLE. The finding of low killing activity in relatives and a correlation between their activity and that of their patients support the view that NK cell deficiency is a genetic determinant of SLE. NK cells in SLE may produce insufficient levels of cytokines required for the regulation of IgG production. |
Databáze: | OpenAIRE |
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