Predictors of COVID-19 severity: a systematic review and meta-analysis
| Autor: | Firzan Nainu, Bagus Aulia Mahdi, Adam Hartono, Hamid Hunaif Dhofi Alluza, Nikma Alfi Rosida, Muchamad Muchlas, Jonny Karunia Fajar, Hamdan Yuwafi Naim, Gatot Soegiarto, Abram L. Wagner, Ali A. Rabaan, Daniel Alexander Suseno, Anita Surya Santoso, Suhendra Suhendra, Mayasari Mayasari, Camoya Gersom, Kartika Agustina, Muhammad Ilmawan, Firman Prastiwi, Harapan Harapan, Sri Masyeni, Richi Aditya, Mudatsir Mudatsir, Romi Hamdani, Yeni Purnamasari, Kuldeep Dhama, Monika Sitio, Abdullah Azmy, Galih Dwi Jayanto, Laksmi Wulandari, Mustofa Mustofa, Radhitio Adi Nugroho, Yennie Ayu Setianingsih, Fransiskus Xaverius Meku |
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| Rok vydání: | 2020 |
| Předmět: |
Coronavirus disease 2019 (COVID-19)
viruses Pneumonia Viral severity clinical outcome Comorbidity 030204 cardiovascular system & hematology Severity of Illness Index General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Betacoronavirus 0302 clinical medicine Risk Factors Medicine Humans 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics Pandemics General Immunology and Microbiology business.industry SARS-CoV-2 virus diseases COVID-19 General Medicine Articles biochemical phenomena metabolism and nutrition digestive system diseases Meta-analysis Systematic Review prognosis business Coronavirus Infections Clinical psychology |
| Zdroj: | F1000Research |
| ISSN: | 2046-1402 |
| Popis: | Background: The unpredictability of the progression of coronavirus disease 2019 (COVID-19) may be attributed to the low precision of the tools used to predict the prognosis of this disease. Objective: To identify the predictors associated with poor clinical outcomes in patients with COVID-19. Methods: Relevant articles from PubMed, Embase, Cochrane, and Web of Science were searched and extracted as of April 5, 2020. Data of interest were collected and evaluated for their compatibility for the meta-analysis. Cumulative calculations to determine the correlation and effect estimates were performed using the Z test. Results: In total, 19 papers recording 1,934 mild and 1,644 severe cases of COVID-19 were included. Based on the initial evaluation, 62 potential risk factors were identified for the meta-analysis. Several comorbidities, including chronic respiratory disease, cardiovascular disease, diabetes mellitus, and hypertension were observed more frequent among patients with severe COVID-19 than with the mild ones. Compared to the mild form, severe COVID-19 was associated with symptoms such as dyspnea, anorexia, fatigue, increased respiratory rate, and high systolic blood pressure. Lower levels of lymphocytes and hemoglobin; elevated levels of leukocytes, aspartate aminotransferase, alanine aminotransferase, blood creatinine, blood urea nitrogen, high-sensitivity troponin, creatine kinase, high-sensitivity C-reactive protein, interleukin 6, D-dimer, ferritin, lactate dehydrogenase, and procalcitonin; and a high erythrocyte sedimentation rate were also associated with severe COVID-19. Conclusion: More than 30 risk factors are associated with a higher risk of severe COVID-19. These may serve as useful baseline parameters in the development of prediction tools for COVID-19 prognosis. |
| Databáze: | OpenAIRE |
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