lndium-111-Labeled Granulocyte Head Accumulation in Patients with Wegener’s Granulomatosis
| Autor: | Loredana Funaro, Pier Giuseppe De Filippi, Dario Roccatello, Giuseppe Picciotto, Giovanni Cacace, Giacomo Quattrocchio, Cristiana Rollino, Giuseppe Piccoli, Graziella Gigliola |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Systemic disease Pathology medicine.medical_specialty Cell Survival Antibodies Antineutrophil Cytoplasmic Organometallic Compounds medicine Humans Radionuclide Imaging Sinusitis Aged Autoantibodies Anti-neutrophil cytoplasmic antibody rhinorrhea business.industry Vascular disease Indium Radioisotopes Granulomatosis with Polyangiitis Middle Aged Oxyquinoline medicine.disease Nephrology Female medicine.symptom Complication Vasculitis business Head Granulocytes Systemic vasculitis |
| Zdroj: | American Journal of Nephrology. 15:500-506 |
| ISSN: | 1421-9670 0250-8095 |
| DOI: | 10.1159/000168894 |
| Popis: | Among the symptoms of systemic vasculitis, purulent rhinorrhea with painful sinusitis is thought to be relatively specific to Wegener's granulomatosis (WG). Sixteen patients with rapidly progressive glomerulonephritis (GN), arteritis and extensive crescents in renal biopsy were studied by head indium-111 (111In)-granulocyte scanning. They included 8 WG, 5 microscopic polyarteritis, 2 necrotizing and crescentic GN and 1 classic polyarteritis nodosa. Autologous granulocytes labeled with 12.3 MBq of 111In-oxine were administered intravenously. Scintigraphic studies were performed at 4 and 24 h post-injection. Compared to the non-WG cases, considered as a whole, significant accumulation of tracer in sinuses was observed in WG patients (Fisher's p = 0.02). Substantial scintigraphic amelioration was obtained in a WG case treated with methylprednisolone pulses and, in another WG case, after high doses of intravenous gamma-globulins. The complete disappearance of facial uptake was obtained after 2 months of intensive therapy (i.e., steroid, cyclophosphamide and plasma exchange) in another WG patient. 111In-oxine granulocyte imaging may be useful in clinical practice as an additional marker of disease activity and a tool of identification of upper respiratory tract involvement. |
| Databáze: | OpenAIRE |
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