The Effect of Anticonvulsant Drugs on GABA-Stimulated Chloride Uptake
| Autor: | W. B. Sneddon, W.M. Burnham, S. J. Mihic, J. Francis |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_treatment Central nervous system In Vitro Techniques Pharmacology Chloride Rats Sprague-Dawley Chlorides medicine Animals gamma-Aminobutyric Acid Chemistry GABAA receptor General Medicine Receptors GABA-A Clonazepam Rats Anticonvulsant medicine.anatomical_structure Neurology Mechanism of action Anticonvulsants Phenobarbital Neurology (clinical) medicine.symptom Diazepam Synaptosomes medicine.drug |
| Zdroj: | Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 21:3-8 |
| ISSN: | 2057-0155 0317-1671 |
| Popis: | Eight anticonvulsant drugs – including clonazepam, diazepam and phenobarbital – were tested for their effects on GABA-stimulated chloride uptake in rat cerebral cortical microsacs (unfiltered synaptoneurosomes). “Mid” and “high” therapeutic concentrations were screened, and, if significant enhancement was found, full concentration-response tests were done. In the initial screens, enhancement of GABA-stimulated uptake was found only with phenobarbital, clonazepam and diazepam. In subsequent concentration-response tests, the effects of phenobarbital were found to occur throughout the range of normal, anticonvulsant concentrations, whereas the effects of clonazepam and diazepam were observed only above the concentrations normally used for the chronic control of seizures or anxiety. These data suggest that phenobarbital's anticonvulsant effects are mediated via the GABAA receptor complex, but that the low-dose effects of the benzodiazepines may be mediated via some other mechanism. |
| Databáze: | OpenAIRE |
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