Human iPS Cell-derived Tissue Engineered Vascular Graft: Recent Advances and Future Directions
Autor: | Shang-Min Zhang, Lile He, Xiangyu Shi, Jiesi Luo |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Interventional therapy Tissue engineered Tissue-Engineered Vascular Graft Computer science Induced Pluripotent Stem Cells Blood Vessel Prosthesis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Tissue engineering 030220 oncology & carcinogenesis Mechanical strength Humans Functional variation Stem cell Induced pluripotent stem cell Biomedical engineering |
Zdroj: | Stem cell reviews and reports. 17(3) |
ISSN: | 2629-3277 |
Popis: | Tissue engineered vascular grafts (TEVGs) generated from human primary cells represent a promising vascular interventional therapy. However, generation and application of these TEVGs may be significantly hindered by the limited accessibility, finite expandability, donor-donor functional variation and immune-incompatibility of primary seed cells from donors. Alternatively, human induced pluripotent stem cells (hiPSCs) offer an infinite source to obtain functional vascular cells in large quantity and comparable quality for TEVG construction. To date, TEVGs (hiPSC-TEVGs) with significant mechanical strength and implantability have been generated using hiPSC-derived seed cells. Despite being in its incipient stage, this emerging field of hiPSC-TEVG research has achieved significant progress and presented promising future potential. Meanwhile, a series of challenges pertaining hiPSC differentiation, vascular tissue engineering technologies and future production and application await to be addressed. Herein, we have composed this review to introduce progress in TEVG generation using hiPSCs, summarize the current major challenges, and encapsulate the future directions of research on hiPSC-based TEVGs. Graphical abstract. |
Databáze: | OpenAIRE |
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