Diabetes is associated with familial idiopathic normal pressure hydrocephalus: a case-control comparison with family members

Autor: Mikko Kauppinen, Jaakko Rinne, Seppo Helisalmi, Cecilia Avellan, Anne M. Koivisto, Sami Kastinen, Mitja I. Kurki, Markus Perola, Joel Huovinen, Mikko Hiltunen, Anne M. Remes, Hilkka Soininen, Antti Ronkainen, Simo Komulainen, Antti Junkkari, Minna Oinas, Joel Rasanen, Ville E. Korhonen, Ville Leinonen, Kimmo Lönnrot, Juha E. Jääskeläinen, Janek Frantzén
Přispěvatelé: Clinicum, HUS Neurocenter, Neurokirurgian yksikkö, University of Helsinki, Helsinki University Hospital Area
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
SYMPTOMS
FEATURES
Comorbidity
Logistic regression
lcsh:RC346-429
3124 Neurology and psychiatry
Comorbidities
MELLITUS
0302 clinical medicine
Familial
Normal pressure hydrocephalus
Epidemiology
EPIDEMIOLOGY
Depression (differential diagnoses)
Aged
80 and over
Depression
Diabetes
Family aggregation
General Medicine
IMPAIRMENT
Middle Aged
Hydrocephalus
Normal Pressure
Exact test
Neurology
Hypertension
NPH
SFMBT1
Female
GLYMPHATIC SYSTEM
MRI
medicine.medical_specialty
Heart Diseases
03 medical and health sciences
Cellular and Molecular Neuroscience
INPH
Developmental Neuroscience
Internal medicine
Diabetes mellitus
medicine
Genetics
Diabetes Mellitus
Humans
Family
Risk factor
VASCULAR RISK-FACTORS
lcsh:Neurology. Diseases of the nervous system
Aged
business.industry
Research
3112 Neurosciences
medicine.disease
030104 developmental biology
Case-Control Studies
business
030217 neurology & neurosurgery
Zdroj: Fluids and Barriers of the CNS
Fluids and Barriers of the CNS, Vol 17, Iss 1, Pp 1-11 (2020)
ISSN: 2045-8118
Popis: Background The pathophysiological basis of idiopathic normal pressure hydrocephalus (iNPH) is still unclear. Previous studies have shown a familial aggregation and a potential heritability when it comes to iNPH. Our aim was to conduct a novel case-controlled comparison between familial iNPH (fNPH) patients and their elderly relatives, involving multiple different families. Methods Questionnaires and phone interviews were used for collecting the data and categorising the iNPH patients into the familial (fNPH) and the sporadic groups. Identical questionnaires were sent to the relatives of the potential fNPH patients. Venous blood samples were collected for genetic studies. The disease histories of the probable fNPH patients (n = 60) were compared with their ≥ 60-year-old relatives with no iNPH (n = 49). A modified Charlson Comorbidity Index (CCI) was used to measure the overall disease burden. Fisher’s exact test (two-tailed), the Mann–Whitney U test (two-tailed) and a multivariate binary logistic regression analysis were used to perform the statistical analyses. Results Diabetes (32% vs. 14%, p = 0.043), arterial hypertension (65.0% vs. 43%, p = 0.033), cardiac insufficiency (16% vs. 2%, p = 0.020) and depressive symptoms (32% vs. 8%, p = 0.004) were overrepresented among the probable fNPH patients compared to their non-iNPH relatives. In the age-adjusted multivariate logistic regression analysis, diabetes remained independently associated with fNPH (OR = 3.8, 95% CI 1.1–12.9, p = 0.030). Conclusions Diabetes is associated with fNPH and a possible risk factor for fNPH. Diabetes could contribute to the pathogenesis of iNPH/fNPH, which motivates to further prospective and gene-environmental studies to decipher the disease modelling of iNPH/fNPH.
Databáze: OpenAIRE
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