Effect of pentylenetetrazol treatment on cholecystokinin mRNA and peptide levels in rat hippocampus and cortex
| Autor: | Shinji Takahashi, Takeshi Kato, Kousuke Nakata, Toshiyuki Chikuma, Katsumichi Takeda |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Hippocampus Peptide Convulsants digestive system Internal medicine Cortex (anatomy) medicine Animals RNA Messenger Pentylenetetrazol Rats Wistar Molecular Biology Cholecystokinin Temporal cortex chemistry.chemical_classification Cerebral Cortex Messenger RNA Chemistry General Neuroscience digestive oral and skin physiology Neuropeptides Rat brain Blotting Northern Immunohistochemistry Rats medicine.anatomical_structure Endocrinology Pentylenetetrazole Neurology (clinical) hormones hormone substitutes and hormone antagonists Developmental Biology medicine.drug |
| Zdroj: | Brain research. 779(1-2) |
| ISSN: | 0006-8993 |
| Popis: | After treatment with pentylenetetrazol (PTZ), cholecystokinin (CCK) mRNA and CCK-like immunoreactivity (CCK-LI) levels were determined in rat hippocampus and cortex at different time points. In the temporal cortex treatment with 60 mg/kg PTZ, i.p., induced increases of CCK mRNA and CCK-LI levels at 2 days after the injection. In the hippocampus, a similar increase of CCK mRNA level was observed on the second day. By contrast, in the frontal cortex, CCK-LI level was increased at 10 days after the treatment with PTZ. These data show that PTZ increases both CCK mRNA and CCK-LI levels in these rat brain regions at different time. |
| Databáze: | OpenAIRE |
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